Now showing items 1-14 of 14

    • Anticipation via canards in excitable systems 

      Köksal Ersöz, E.; Desroches, M.Autoridad BCAM; Mirasso, C.; Rodrigues, S.Autoridad BCAM (2019-01-14)
      Neurons can anticipate incoming signals by exploiting a physiological mechanism that is not well understood. This article offers a novel explanation on how a receiver neuron can predict the sender’s dynamics in a ...
    • Are Brain-Computer Interfaces Feasible withIntegrated Photonic Chips? 

      Salari, V.; Rodrigues, S.Autoridad BCAM; Saglamyurek, E.; Simon, C.; Oblak, D. (2021-11)
      The present paper examines the viability of a radically novel idea for brain-computer interface (BCI), which could lead to novel technological, experimental and clinical applications. BCIs are computer-based systems that ...
    • Classification of bursting patterns: A tale of two ducks 

      Desroches, M.Autoridad BCAM; Rinzel, J.; Rodrigues, S.Autoridad BCAM (2022-01-20)
      Bursting is one of the fundamental rhythms that excitable cells can generate either in response to incoming stimuli or intrinsically. It has been a topic of intense research in computational biology for several decades. ...
    • Conductance-Based Refractory Density Approach for a Population of Bursting Neurons 

      Chizhov, A.; Campillo, F.; Desroches, M.Autoridad BCAM; Guillamon A; Rodrigues, S.Autoridad BCAM (2019)
      The conductance-based refractory density (CBRD) approach is a parsimonious mathematical-computational framework for modeling interact- ing populations of regular spiking neurons, which, however, has not been yet extended ...
    • Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease 

      Munawara, U.; Catanzaro, M.; Xu, W.; Tan, C.; Hirokawa, K.; Bosco, N.; Dumoulin, D.; Khalil, A.; Larbi, A.; Lévesque, S.; Ramassamy, C.; Barron, A.; Cunnane, S.; Beauregard, P.; Bellenger, J.P.; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Witkowski, J.M.; Laurent, B.; Frost, E.; Fülöp, T. (2021-12-01)
      Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related ...
    • Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change 

      Fülöp, T.; Larbi, A.; Pawelec, G.; Cohen, A.; Provost, G.; Khalil, A.; Lacombe, G.; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Hirokawa, K.; Franceschi, C.; Witkowski, J.M. (2022-04-01)
      Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as ...
    • Inflection, Canards and Folded Singularities in Excitable Systems: Application to a 3D FitzHugh–Nagumo Model 

      Uria-Albizuri, J.; Desroches, M.Autoridad BCAM; Krupa, M.; Rodrigues, S.Autoridad BCAM (2020-09-07)
      Specific kinds of physical and biological systems exhibit complex Mixed-Mode Oscillations mediated by folded-singularity canards in the context of slow-fast models. The present manuscript revisits these systems, specifically ...
    • Metastable resting state brain dynamics 

      beim Graben, P.; Jimenez-Marin, A.; Diez, I.; Cortes, J.M.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM (2019-09-06)
      Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ...
    • A phenomenological model for interfacial water near hydrophilic polymers 

      Earls, A.; Calderer, M.-C.; Desroches, M.Autoridad BCAM; Zarnescu, A.Autoridad BCAM; Rodrigues, S.Autoridad BCAM (2022-06-30)
      We propose a minimalist phenomenological model for the ‘interfacial water’ phenomenon that occurs near hydrophilic polymeric surfaces. We achieve this by combining a Ginzburg–Landau approach with Maxwell’s equations which ...
    • Spike-adding and reset-induced canard cycles in adaptive integrate and fire models 

      Desroches, M.Autoridad BCAM; Kowalczyk, P.; Rodrigues, S.Autoridad BCAM (2021-05-03)
      We study a class of planar integrate and fire (IF) models called adaptive integrate and fire (AIF) models, which possesses an adaptation vari- able on top of membrane potential, and whose subthreshold dynamics is piece- ...
    • Stochastic facilitation in heteroclinic communication channels 

      Sirio Carmantini, G.; Schittler Neves, F.; Timme, M.; Rodrigues, S.Autoridad BCAM (2021-09-01)
      Biological neural systems encode and transmit information as patterns of activity tracing complex trajectories in high-dimensional state spaces, inspiring alternative paradigms of information processing. Heteroclinic ...
    • Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease 

      Fülöp, T.; Tripathi, S.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Bunt, T.; Eiser, A.; Bernier, F.; Beauregard, P.; Barron, A.; Khalil, A.; Plotka, A.; Hirokawa, K.; Larbi, A.; Bocti, C.; Laurent, B.; Frost, E.; Witkowski, J. (2021-05-04)
      Alzheimer’s disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease. The etiology of AD is not known but AD may be considered as a clinical syndrome with multiple ...
    • Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease 

      Fülöp, T.; Munawara, U.; Larbi, A.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Catanzaro, M.; Guidolin, A.; Khalil, A.; Bernier, F.; Barron, A.E.; Hirokawa, K.; Beauregard, P.B.; Dumoulin, D.; Bellenger, J.-P.; Witkowski, J.M.; Frost, E. (2020-05-26)
      Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of ...
    • Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing” 

      Fülöp, T.; Desroches, M.Autoridad BCAM; Cohen, A.; Santos, F.A.N.; Rodrigues, S.Autoridad BCAM (2020-10-27)
      Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be ...