Browsing by Author "RodríguezÁlvarez, M.X."
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Bayesian hierarchical modelling of growth curve derivatives via sequences of quotient differences
Page, G.L.; RodríguezÁlvarez, M.X.; Lee, D.J. (202001)Growth curve studies are typically conducted to evaluate differences between group or treatmentspecific curves. Most analyses focus solely on the growth curves, but it has been argued that the derivative of growth curves ... 
Bayesian nonparametric inference for the covariateadjusted ROC curve
Inacio de Carvalho, V.; RodríguezÁlvarez, M.X. (20180530)Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between diseased and nondiseased ... 
Bootstrapbased procedures for inference in nonparametric receiveroperating characteristic curve regression analysis
RodríguezÁlvarez, M.X.; RocaPardiñas, J.; CadarsoSuárez, C.; Tahoces, P.G. (2017)Prior to using a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is essential. The receiveroperating characteristic curve is the measure of accuracy most widely used for ... 
Bootstrapbased procedures for inference in nonparametric ROC regression analysis
RodríguezÁlvarez, M.X.; RocaPardiñas, J.; CadarsoSuárez, C.; Tahoces, P.G. (20160630)Before the use of a diagnostic test in a routine clinical setting, the rigorous evaluation of its diagnostic accuracy is an essential step. The receiver operating characteristic (ROC) curve is the measure of accuracy most ... 
Comparison of two discrimination indexes in the categorisation of continuous predictors in timetoevent studies
Barrio, I.; RodríguezÁlvarez, M.X.; MeiraMachado, L.; Esteban, C.; Arostegui, I. (201704)The Cox proportional hazards model is the most widely used survival prediction model for analysing timetoevent data. To measure the discrimination ability of a survival model the concordance probability index is widely ... 
Correcting for spatial heterogeneity in plant breeding experiments with Psplines
RodríguezÁlvarez, M.X.; Boer, M.P.; van Eeuwijk, F.A.; Eilers, P.H.C. (20171027)An important aim of the analysis of agricultural field experiments is to obtain good predictions for genotypic performance, by correcting for spatial effects. In practice these corrections turn out to be complicated, since ... 
Fast algorithm for smoothing parameter selection in multidimensional Psplines
RodríguezÁlvarez, M.X.; Lee, D.J.; Kneib, T.; Durban, M.; Eilers, P.H.C. (20151231)A new computational algorithm for estimating the smoothing parameters of a multidimensional penalized spline generalized model with anisotropic penalty is presented. This new proposal is based on the mixed model representation ... 
Fast estimation of multidimensional adaptive Pspline models
RodríguezÁlvarez, M.X.; Durban, M.; Lee, D.J.; Eilers, P.H.C. (20161021)A fast and stable algorithm for estimating multidimensional adaptive Pspline models is presented. We call it as Separation of Overlapping Penalties (SOP) as it is an extension of the Separation of Anisotropic Penalties ... 
Fast smoothing parameter separation in multidimensional generalized Psplines: the SAP algorithm
RodríguezÁlvarez, M.X.; Lee, D.J.; Kneib, T.; Durban, M.; Eilers, P.H.C. (20141231)A new computational algorithm for estimating the smoothing parameters of a multidimensional penalized spline generalized linear model with anisotropic penalty is presented. This new proposal is based on the mixed model ... 
Modelling spatial trends in sorghum breeding field trials using a twodimensional Pspline mixed model
Velazco, J.G.; RodríguezÁlvarez, M.X.; Boer, M.P.; Jordan, D.R.; Eilers, P.H.C.; Malosetti, M.; van Eeuwijk, F. (20170403)Adjustment for spatial trends in plant breeding field trials is essential for efficient evaluation and selection of genotypes. Current mixed model methods of spatial analysis are based on a multistep modelling process ... 
A new approach to categorize continuous variables in prediction models: Proposal and validation
Barrio, I.; Arostegui, I.; RodríguezÁlvarez, M.X.; Quintana, J.M. (201712)When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded as advisable from ... 
On the estimation of variance parameters in nonstandard generalised linear mixed models: Application to penalised smoothing
RodríguezÁlvarez, M.X.; Durban, M.; Lee, D.J.; Eilers, P.H.C. (20180124)We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (1977)'s work, but it is able to deal with models that have a precision matrix ... 
Package wsbackfit for Smooth Backfitting Estimation of Generalized Structured Models
RocaPardinas, J.; RodríguezÁlvarez, M.X.; Sperlich, S. (20210101)A package is introduced that provides the weighted smooth backfitting estimator for a large family of popular semiparametric regression models. This family is known as generalized structured models, comprising, for example, ... 
Phenomics data processing: A plotlevel model for repeated measurements to extract the timing of key stages and quantities at defined time points
Roth, L.; Van Eeuwijk, F.; RodríguezÁlvarez, M.X.; HansPeter, P.; Hund, A. (2021)Decisionmaking in breeding increasingly depends on the ability to capture and predict crop responses to changing environmental factors. Advances in crop modeling as well as highthroughput eld phenotyping (HTFP) hold ... 
ROCnReg: An R Package for Receiver Operating Characteristic Curve Inference With and Without Covariates
RodríguezÁlvarez, M.X.; Vanda, I. (20210101)This paper introduces the package ROCnReg that allows estimating the pooled ROC curve, the covariatespecific ROC curve, and the covariateadjusted ROC curve by different methods, both from (semi) parametric and nonparametric ... 
Sample size impact on the categorisation of continuous variables in clinical prediction
Barrio, I.; Arostegui, I.; RodríguezÁlvarez, M.X. (201712)Recent advances in information technologies are generating a growth in the amount of available biomedical data. In this paper, we studied the impact sample size may have on the categorisation of a continuous predictor ... 
Spatial Models for Field Trials
RodríguezÁlvarez, M.X.; Boer, M.P.; Eeuwijk, F.; Eilers, P.H.C. (20160901)An important aim of the analysis of agricultural field trials is to obtain good predictions for genotypic performance, by correcting for spatial effects. In practice these corrections turn out to be complicated, since there ... 
Spatiotemporal adaptive penalized splines with application to Neuroscience
RodríguezÁlvarez, M.X.; Durban, M.; Lee, D.J.; Eilers, P.H.C.; Gonzalez, F (20161230)Data analysed here derive from experiments conducted to study neurons' activity in the visual cortex of behaving monkeys. We consider a spatiotemporal adaptive penalized spline (Pspline) approach for modelling the firing ... 
A twostage approach for the spatiotemporal analysis of highthroughput phenotyping data
Pérez, D.M.; RodríguezÁlvarez, M.X.; Boer, M.P; Kronenberg, L.; Hund, A.; CabreraBosquet, L.; Millet, E.J.; van Eeuwijk, F.A. (20220224)High throughput phenotyping (HTP) platforms and devices are increasingly used for the characterization of growth and developmental processes for large sets of plant genotypes. Such HTP data require challenging statistical ...