Applied Statistics
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Optimal experimental design for cytogenetic dose-response calibration curves
(2019)Purpose: To introduce optimal experimental design techniques in the cytogenetic biological dosimetry practice. This includes the development of a new optimality criterion for the calibration of radiation doses. Materials ... -
Spatial Bayesian Modeling Applied to the Surveys of Xylella fastidiosa in Alicante (Spain) and Apulia (Italy)
(2020)The plant-pathogenic bacterium Xylella fastidiosa was first reported in Europe in 2013, in the province of Lecce, Italy, where extensive areas were affected by the olive quick decline syndrome, caused by the subsp. pauca. ... -
Ecological, genetic and evolutionary drivers of regional genetic differentiation in Arabidopsis thaliana
(2020)Background: Disentangling the drivers of genetic differentiation is one of the cornerstones in evolution. This is because genetic diversity, and the way in which it is partitioned within and among populations across space, ... -
Disease progression of peach powdery mildew in Catalonia, Spain – Towards a decision support system based on degree-days to initiate fungicide spray programs
(2020)The incidence of peach powdery mildew (PPM) on fruit was monitored in commercial peach orchards to i) describe the disease progress in relation to several environmental parameters and ii) establish an operating threshold ... -
Comparison of Frequentist and Bayesian Meta-Analysis Models for Assessing the Efficacy of Decision Support Systems in Reducing Fungal Disease Incidence
(2020)Diseases of fruit and foliage caused by fungi and oomycetes are generally controlled by the application of fungicides. The use of decision support systems (DSSs) may assist to optimize fungicide programs to enhance application ... -
Predictive factors over time of health-related quality of life in chronic obstructive pulmonary disease patients
(2020-01)Background: Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated ... -
Bayesian hierarchical modelling of growth curve derivatives via sequences of quotient differences
(2020-01)Growth curve studies are typically conducted to evaluate differences between group or treatment-specific curves. Most analyses focus solely on the growth curves, but it has been argued that the derivative of growth curves ... -
idmTPreg: Regression Model for Progressive Illness Death Data
(2018-12-01)The progressive illness-death model is frequently used in medical applications. For example, the model may be used to describe the disease process in cancer studies. We have developed a new R package called idmTPreg to ... -
A General Framework for Prediction in Generalized Additive Models
(2020-01-13)Smoothing techniques have become one of the most popular modelling approaches in the unidimensional and multidimensional setting. However, out-of-sample prediction in the context of smoothing models is still an open problem ... -
Modelling species presence–absence in the ecological niche theory framework using shape-constrained generalized additive models
(2020-01-13)According to ecological niche theory, species response curves are unimodal with respect to environmental gradients. A variety of statistical methods have been developed for species distribution modelling. A general problem ... -
Robust combination of the Morris and Sobol methods in complex multidimensional models
(2019)Conducting global sensitivity analysis using variance decomposition methods in complex simulation models with many input factors is usually unaffordable. An alternative is to first apply a screening method to reduce the ... -
Poisson excess relative risk models: New implementations and software
(2019-03-01)Two new implementations for fitting Poisson excess relative risk methods are proposed for assumed simple models. This allows for estimation of the excess relative risk associated with a unique exposure, where the background ... -
Anxiety and depressive symptoms are related to core symptoms, general helath outcome and medical comorbidities in eating disorders
(2019-04)Objective: The goal of this study is to identify potential factors that have a significant effect on anxiety and depression of patients with eating disorders (ED) using the beta-binomial regression (BBR) approach on a broad ... -
COPD classification models and mortality prediction capacity
(2019)Our aim was to assess the impact of comorbidities on existing COPD prognosis scores. Patients and methods: A total of 543 patients with COPD (FEV1 < 80% and FEV1/ FVC <70%) were included between January 2003 and January ... -
Predictors of one and two years’ mortality in patients with colon cancer: a prospective cohort study
(2018)Tools to aid in the prognosis assessment of colon cancer patients in terms of risk of mortality are needed. Goals of this study are to develop and validate clinical prediction rules for 1-and 2-year mortality in these ... -
A beta-binomial mixed-effects model approach for analysing longitudinal discrete and bounded outcomes
(2018-05)Patient-reported outcomes (PROs) are currently being increasingly used as primary outcome measures in observational and experimental studies since they inform clinicians and researchers about the health-status of patients ... -
A statistical framework for radiation dose estimation with uncertainty quantification from the γ-H2AX assay
(2018-11-28)Over the last decade, the γ–H2AX focus assay, which exploits the phosphorylation of the H2AX histone following DNA double–strand–breaks, has made considerable progress towards acceptance as a reliable biomarker for exposure ... -
A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples
(2018-06-13)Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations ... -
Bayesian nonparametric inference for the covariate-adjusted ROC curve
(2018-05-30)Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between diseased and nondiseased ... -
Dicentric dose estimates for patients undergoing radiotherapy in the RTGene study to assess blood dosimetric models and the new Bayesian method for gradient exposure
(2018-06-01)The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy (RT) patient responses to ionising radiation (IR). In parallel, for validation ...
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