Now showing items 30-49 of 59

• A General Framework for Prediction in Generalized Additive Models ﻿

(2020-01-13)
Smoothing techniques have become one of the most popular modelling approaches in the unidimensional and multidimensional setting. However, out-of-sample prediction in the context of smoothing models is still an open problem ...
• Hierarchical modelling of patient-reported outcomes data based on the beta-binomial distribution ﻿

(2017-12-13)
The beta-binomial distribution does not belong to the exponential family and, hence classical regression techniques cannot be used when dealing with outcomes following the mentioned distribution. In this thesis we propose ...
• idmTPreg: Regression Model for Progressive Illness Death Data ﻿

(2018-12-01)
The progressive illness-death model is frequently used in medical applications. For example, the model may be used to describe the disease process in cancer studies. We have developed a new R package called idmTPreg to ...
• Modelling latent trends from spatio-temporally grouped data using composite link mixed models ﻿

(2016-07)
Epidemiological data are frequently recorded at coarse spatio-temporal resolutions. The aggregation process is done for several reasons: to protect confidential patients' information, to compare with other datasets at a ...
• Modelling spatial trends in sorghum breeding field trials using a two-dimensional P-spline mixed model ﻿

(2017-04-03)
Adjustment for spatial trends in plant breeding field trials is essential for efficient evaluation and selection of genotypes. Current mixed model methods of spatial analysis are based on a multi-step modelling process ...
• Modelling species presence–absence in the ecological niche theory framework using shape-constrained generalized additive models ﻿

(2020-01-13)
According to ecological niche theory, species response curves are unimodal with respect to environmental gradients. A variety of statistical methods have been developed for species distribution modelling. A general problem ...
• A new approach to categorize continuous variables in prediction models: Proposal and validation ﻿

(2017-12)
When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded as advisable from ...
• A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples ﻿

(2018-06-13)
Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations ...
• On the estimation of variance parameters in non-standard generalised linear mixed models: Application to penalised smoothing ﻿

(2018-01-24)
We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (1977)'s work, but it is able to deal with models that have a precision matrix ...
• Optimal experimental design for cytogenetic dose-response calibration curves ﻿

(2019)
Purpose: To introduce optimal experimental design techniques in the cytogenetic biological dosimetry practice. This includes the development of a new optimality criterion for the calibration of radiation doses. Materials ...
• Penalized composite link mixed models for two-dimensional count data ﻿

(2015-05)
Mortality data provide valuable information for the study of the spatial distribution of mortality risk, in disciplines such as spatial epidemiology, medical demography, and public health. However, they are often available ...
• Penalized composite link models for aggregated spatial count data: a mixed model approach ﻿

(2016-01-01)
Mortality data provide valuable information for the study of the spatial distri- bution of mortality risk, in disciplines such as spatial epidemiology and public health. However, they are frequently available in an aggregated ...
• Poisson excess relative risk models: New implementations and software ﻿

(2019-03-01)
Two new implementations for fitting Poisson excess relative risk methods are proposed for assumed simple models. This allows for estimation of the excess relative risk associated with a unique exposure, where the background ...
• Predicting Pregnancy Outcomes Using Longitudinal Information: A Penalized Splines Mixed–Effects Model Approach ﻿

(2017-02-09)
We propose a semiparametric mixed–effects model (SNMM) using penalized splines to clas- sify longitudinal data and improve the prediction of a binary outcome. The work is motivated by a study in which different hormone ...
• Predictive factors over time of health-related quality of life in chronic obstructive pulmonary disease patients ﻿

(2020-01)
Background: Health-related quality of life (HRQoL) should be seen as a tool that provides an overall view of the general clinical condition of a COPD patient. The aims of this study were to identify variables associated ...
• Predictors of one and two years’ mortality in patients with colon cancer: a prospective cohort study ﻿

(2018)
Tools to aid in the prognosis assessment of colon cancer patients in terms of risk of mortality are needed. Goals of this study are to develop and validate clinical prediction rules for 1-and 2-year mortality in these ...
• Robust combination of the Morris and Sobol methods in complex multidimensional models ﻿

(2019)
Conducting global sensitivity analysis using variance decomposition methods in complex simulation models with many input factors is usually unaffordable. An alternative is to first apply a screening method to reduce the ...
• Sample size impact on the categorisation of continuous variables in clinical prediction ﻿

(2017-12)
Recent advances in information technologies are generating a growth in the amount of available biomedical data. In this paper, we studied the impact sample size may have on the categorisation of a continuous predictor ...
• A simple Bayesian linear excess relative risk model ﻿

(2017-07-11)
A new Bayesian Poisson relative risk model is proposed for displaying the excess relative risk associated to a unique exposure as a probability distribution in a closed form. The background risk can be modelled by a unique ...
• Simulation approach for assessing the performance of the γEWMA control chart ﻿

(2021-02-22)
i) Purpose: The purpose of this paper is to evaluate the performance of a modified EWMA control chart ($\gamma$EWMA control chart), which considers data distribution and incorporate its correlation structure, simulating ...