Now showing items 1-4 of 4
A statistical framework for radiation dose estimation with uncertainty quantification from the γ-H2AX assay
Over the last decade, the γ–H2AX focus assay, which exploits the phosphorylation of the H2AX histone following DNA double–strand–breaks, has made considerable progress towards acceptance as a reliable biomarker for exposure ...
Dicentric dose estimates for patients undergoing radiotherapy in the RTGene study to assess blood dosimetric models and the new Bayesian method for gradient exposure
The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy (RT) patient responses to ionising radiation (IR). In parallel, for validation ...
An exact goodness-of-fit test based on the occupancy problems to study zero-inflation and zero-deflation in biological dosimetry data
The goal in biological dosimetry is to estimate the dose of radiation that a suspected irradiated individual has received. For that, the analysis of aberrations (most commonly dicentric chromosome aberrations) in scored ...
Uncertainty on radiation doses estimated by biological and retrospective physical methods
Biological and physical retrospective dosimetry are recognised as key techniques to provide individual estimates of dose following unplanned exposures to ionising radiation. Whilst there has been a relatively large amount ...