High throughput phenotyping (HTP) platforms and devices are increasingly used for the characterization of growth and developmental processes for large sets of plant genotypes. Such HTP data require challenging statistical ...

This paper introduces the package ROCnReg that allows estimating the pooled ROC curve, the covariate-specific ROC curve, and the covariate-adjusted ROC curve by different methods, both from (semi) parametric and nonparametric ...

A package is introduced that provides the weighted smooth backfitting estimator for a large family of popular semiparametric regression models. This family is known as generalized structured models, comprising, for example, ...

Decision-making in breeding increasingly depends on the ability to capture and predict crop responses to changing environmental factors. Advances in crop modeling as well as high-throughput eld phenotyping (HTFP) hold ...

Growth curve studies are typically conducted to evaluate differences between group or treatment-specific curves. Most analyses focus solely on the growth curves, but it has been argued that the derivative of growth curves ...

Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between diseased and nondiseased ...

We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (1977)'s work, but it is able to deal with models that have a precision matrix ...

Recent advances in information technologies are generating a growth in the amount of available biomedical data. In this paper, we studied the impact sample size may have on the categorisation of a continuous predictor ...

When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded as advisable from ...

An important aim of the analysis of agricultural field experiments is to obtain good predictions for genotypic performance, by correcting for spatial effects. In practice these corrections turn out to be complicated, since ...