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Poisson excess relative risk models: New implementations and software
(2019-03-01)
Two new implementations for fitting Poisson excess relative risk methods are proposed for assumed simple models. This allows for estimation of the excess relative risk associated with a unique exposure, where the background ...
Optimal experimental design for cytogenetic dose-response calibration curves
(2019)
Purpose: To introduce optimal experimental design techniques in the cytogenetic biological dosimetry practice. This includes the development of a new optimality criterion for the calibration of radiation doses.
Materials ...
A statistical framework for radiation dose estimation with uncertainty quantification from the γ-H2AX assay
(2018-11-28)
Over the last decade, the γ–H2AX focus assay, which exploits the phosphorylation of the H2AX histone following DNA double–strand–breaks, has made considerable progress towards acceptance as a reliable biomarker for exposure ...
A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples
(2018-06-13)
Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations ...
Dicentric dose estimates for patients undergoing radiotherapy in the RTGene study to assess blood dosimetric models and the new Bayesian method for gradient exposure
(2018-06-01)
The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy (RT) patient responses to ionising radiation (IR). In parallel, for validation ...
Cancer incidence among children and young adults who have undergone x-ray guided cardiac catheterization procedures
(2018-01-18)
Children and young adults with heart disease appear to be at increased risk of developing cancer, although the reasons for this are unclear. A cohort of 11,270 individuals, who underwent cardiac catheterizations while aged ...
An exact goodness-of-fit test based on the occupancy problems to study zero-inflation and zero-deflation in biological dosimetry data
(2018-01-12)
The goal in biological dosimetry is to estimate the dose of radiation that a suspected irradiated individual has received. For that, the analysis of aberrations (most commonly dicentric chromosome aberrations) in scored ...
Uncertainty on radiation doses estimated by biological and retrospective physical methods
(2017-09-18)
Biological and physical retrospective dosimetry are recognised as key techniques to provide individual estimates of dose following unplanned exposures to ionising radiation. Whilst there has been a relatively large amount ...
A simple Bayesian linear excess relative risk model
(2017-07-11)
A new Bayesian Poisson relative risk model is proposed for displaying the excess relative risk associated to a unique exposure as a probability distribution in a closed form. The background risk can be modelled by a unique ...