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Hierarchical modelling of patient-reported outcomes data based on the beta-binomial distribution
(2017-12-13)
The beta-binomial distribution does not belong to the exponential family and, hence classical regression techniques
cannot be used when dealing with outcomes following the mentioned distribution.
In this thesis we propose ...
A new approach to categorize continuous variables in prediction models: Proposal and validation
(Statistical Methods in Medical Research, 2017-12)
When developing prediction models for application in clinical practice, health practitioners
usually categorise clinical variables that are continuous in nature. Although categorisation is not
regarded as advisable from ...
Sample size impact on the categorisation of continuous variables in clinical prediction
(Trends in Mathematics. Research Perspectives CRM Barcelona. Extended Abstracts Fall 2015. Biomedical Big Data; Statistics for Low Dose Radiation Research, 2017-12)
Recent advances in information technologies are generating a growth in the amount of available biomedical data. In this paper, we studied the impact sample size may have on the categorisation of a continuous predictor ...
Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma
(BBA Clinical, 2017-12)
Purpose
Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these ...
Correcting for spatial heterogeneity in plant breeding experiments with P-splines
(Spatial Statistics, 2017-10-27)
An important aim of the analysis of agricultural field experiments is to obtain good predictions for genotypic performance, by correcting for spatial effects. In practice these corrections turn out to be complicated, since ...
Uncertainty on radiation doses estimated by biological and retrospective physical methods
(Radiation Protection Dosimetry, 2017-09-18)
Biological and physical retrospective dosimetry are recognised as key techniques to provide individual estimates of dose following unplanned exposures to ionising radiation. Whilst there has been a relatively large amount ...
A simple Bayesian linear excess relative risk model
(2017-07-11)
A new Bayesian Poisson relative risk model is proposed for displaying the excess relative risk associated to a unique exposure as a probability distribution in a closed form. The background risk can be modelled by a unique ...
Modelling spatial trends in sorghum breeding field trials using a two-dimensional P-spline mixed model
(Theoretical and Applied Genetics, 2017-04-03)
Adjustment for spatial trends in plant breeding field trials is essential for efficient evaluation and selection of genotypes. Current mixed model methods of spatial analysis are based on a multi-step modelling process ...
Comparison of two discrimination indexes in the categorisation of continuous predictors in time-to-event studies
(SORT (Statistics and Operations Research Transactions), 2017-04)
The Cox proportional hazards model is the most widely used survival prediction model for analysing timeto-event data. To measure the discrimination ability of a survival model the concordance probability index is widely ...
Acute toxicity, bioaccumulation and effects of dietary 1 transfer of silver from brine 2 shrimps exposed to PVP/PEI-coated silver nanoparticles to zebrafish
(Comparative Biochemistry and Physiology - part C: Toxicology & Pharmacology, 2017-03-18)
The extensive use and release to the aquatic environment of silver nanoparticles (NPs) could lead to their incorporation into the food web. Brine shrimp larvae of 24 h showed low sensitivity to the exposure to PVP/PEI-coated ...