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Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma
Purpose Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these ...
Effect of trampling and digging from shell shing on Zostera noltei (Zosteraceae) intertidal seagrass beds
Seagrass beds are among the most valuable ecosystems in the world but they are also among the ones most affected by human activities, and they have decreased significantly in recent decades. In many areas, such as in the ...
Predicting Pregnancy Outcomes Using Longitudinal Information: A Penalized Splines Mixed–Effects Model Approach
We propose a semiparametric mixed–effects model (SNMM) using penalized splines to clas- sify longitudinal data and improve the prediction of a binary outcome. The work is motivated by a study in which different hormone ...
Comparison of beta-binomial regression model approaches to analyze health related quality of life data
Health related quality of life (HRQoL) has become an increasingly important indicator of health status in clinical trials and epidemiological research. Moreover, the study of the relationship of HRQoL with patients' and ...