Now showing items 1-10 of 46
Anxiety and depressive symptoms are related to core symptoms, general helath outcome and medical comorbidities in eating disorders
(European Eating Disorders Review, 2019-04)
Objective: The goal of this study is to identify potential factors that have a significant effect on anxiety and depression of patients with eating disorders (ED) using the beta-binomial regression (BBR) approach on a broad ...
Poisson excess relative risk models: New implementations and software
Two new implementations for fitting Poisson excess relative risk methods are proposed for assumed simple models. This allows for estimation of the excess relative risk associated with a unique exposure, where the background ...
COPD classification models and mortality prediction capacity
(International Journal of COPD, 2019)
Our aim was to assess the impact of comorbidities on existing COPD prognosis scores. Patients and methods: A total of 543 patients with COPD (FEV1 < 80% and FEV1/ FVC <70%) were included between January 2003 and January ...
Robust combination of the Morris and Sobol methods in complex multidimensional models
(Environmental Modelling and Software, 2019)
Conducting global sensitivity analysis using variance decomposition methods in complex simulation models with many input factors is usually unaffordable. An alternative is to first apply a screening method to reduce the ...
A statistical framework for radiation dose estimation with uncertainty quantification from the γ-H2AX assay
(PLoS ONE, 2018-11-28)
Over the last decade, the γ–H2AX focus assay, which exploits the phosphorylation of the H2AX histone following DNA double–strand–breaks, has made considerable progress towards acceptance as a reliable biomarker for exposure ...
A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples
(International Journal of Radiation Biology, 2018-06-13)
Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations ...
Dicentric dose estimates for patients undergoing radiotherapy in the RTGene study to assess blood dosimetric models and the new Bayesian method for gradient exposure
The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy (RT) patient responses to ionising radiation (IR). In parallel, for validation ...
Bayesian nonparametric inference for the covariate-adjusted ROC curve
Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between diseased and nondiseased ...
A beta-binomial mixed-effects model approach for analysing longitudinal discrete and bounded outcomes
(Biometrical Journal, 2018-05)
Patient-reported outcomes (PROs) are currently being increasingly used as primary outcome measures in observational and experimental studies since they inform clinicians and researchers about the health-status of patients ...
Suggestion of reduced cancer risks following cardiac x-ray exposures is unconvincing
(European Journal of Epidemiology, 2018-03-31)