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A statistical framework for radiation dose estimation with uncertainty quantification from the γ-H2AX assay
(PLoS ONE, 2018-11-28)
Over the last decade, the γ–H2AX focus assay, which exploits the phosphorylation of the H2AX histone following DNA double–strand–breaks, has made considerable progress towards acceptance as a reliable biomarker for exposure ...
A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples
(International Journal of Radiation Biology, 2018-06-13)
Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations ...
Dicentric dose estimates for patients undergoing radiotherapy in the RTGene study to assess blood dosimetric models and the new Bayesian method for gradient exposure
(2018-06-01)
The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy (RT) patient responses to ionising radiation (IR). In parallel, for validation ...
Bayesian nonparametric inference for the covariate-adjusted ROC curve
(2018-05-30)
Accurate diagnosis of disease is of fundamental importance in clinical practice and medical research. Before a medical diagnostic test is routinely used in practice, its ability to distinguish between diseased and nondiseased ...
A beta-binomial mixed-effects model approach for analysing longitudinal discrete and bounded outcomes
(Biometrical Journal, 2018-05)
Patient-reported outcomes (PROs) are currently being increasingly used as primary outcome measures in observational and experimental studies since they inform clinicians and researchers about the health-status of patients ...
Suggestion of reduced cancer risks following cardiac x-ray exposures is unconvincing
(European Journal of Epidemiology, 2018-03-31)
Combining statistical techniques to predict post-surgical risk of 1-year mortality for patients with colon cancer
(Clinical Epidemiology, 2018-03-06)
Introduction: Colorectal cancer is one of the most frequently diagnosed malignancies and a common cause of cancer-related mortality. The aim of this study was to develop and validate a clinical predictive model for1-year ...
On the estimation of variance parameters in non-standard generalised linear mixed models: Application to penalised smoothing
(Statistics and Computing, 2018-01-24)
We present a novel method for the estimation of variance parameters in generalised linear mixed models. The method has its roots in Harville (1977)'s work, but it is able to deal with models that have a precision matrix ...
Cancer incidence among children and young adults who have undergone x-ray guided cardiac catheterization procedures
(European Journal of Epidemiology, 2018-01-18)
Children and young adults with heart disease appear to be at increased risk of developing cancer, although the reasons for this are unclear. A cohort of 11,270 individuals, who underwent cardiac catheterizations while aged ...
An exact goodness-of-fit test based on the occupancy problems to study zero-inflation and zero-deflation in biological dosimetry data
(Radiation Protection Dosimetry, 2018-01-12)
The goal in biological dosimetry is to estimate the dose of radiation that a suspected irradiated individual has received. For that, the analysis of aberrations (most commonly dicentric chromosome aberrations) in scored ...