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dc.contributor.authorKroos J.M.en_US
dc.contributor.authorde Tommaso M.en_US
dc.contributor.authorStramaglia S.en_US
dc.contributor.authorVecchio E.en_US
dc.contributor.authorBurdi N.en_US
dc.contributor.authorGerardo-Giorda L.en_US
dc.date.accessioned2019-10-11T06:29:17Z
dc.date.available2019-10-11T06:29:17Z
dc.date.issued2019-07-28
dc.identifier.urihttp://hdl.handle.net/20.500.11824/1027
dc.description.abstractIntroduction: Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis that CSD is underlying migraine aura. The highly individual and complex characteristics of the brain cor‐ tex suggest that the geometry might impact the propagation of cortical spreading depression. Methods: In a single‐case study, we simulated the CSD propagation for five migraine with aura patients, matching their symptoms during a migraine attack to the CSD wavefront propagation. This CSD wavefront was simulated on a patient‐specific tri‐ angulated cortical mesh obtained from individual MRI imaging and personalized dif‐ fusivity tensors derived locally from diffusion tensor imaging data. Results: The CSD wave propagation was simulated on both hemispheres, despite in all but one patient the symptoms were attributable to one hemisphere. The CSD wave diffused with a large wavefront toward somatosensory and prefrontal regions, devoted to pain processing. Discussion: This case‐control study suggests that the cortical geometry may con‐ tribute to the modality of CSD evolution and partly to clinical expression of aura symptoms. The simulated CSD is a large and diffuse phenomenon, possibly capa‐ ble to activate trigeminal nociceptors and to involve cortical areas devoted to pain processing.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherBrain and Behavioren_US
dc.relationES/1PE/SEV-2017-0718en_US
dc.relationES/1PE/MTM2015-69992-Ren_US
dc.relationES/2PE/RTI2018-093416-B-I00en_US
dc.relationEUS/BERC/BERC.2018-2021en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/en_US
dc.subjectcortical spreading depressionen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectfinite element methoden_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectmigraine with auraen_US
dc.subjectpatient‐specific mathematical modelen_US
dc.titleClinical correlates of mathematical modeling of cortical spreading depression: Single‐cases studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeinfo:eu-repo/semantics/publishedVersionen_US
dc.identifier.doi10.1002/brb3.1387
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/brb3.1387en_US


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