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dc.contributor.authorTadic, B.
dc.contributor.authorAndjelkovic, M.
dc.contributor.authorMelnik, R. 
dc.date.accessioned2019-12-18T08:36:26Z
dc.date.available2019-12-18T08:36:26Z
dc.date.issued2019-08
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/20.500.11824/1056
dc.description.abstractMapping the brain imaging data to networks, where nodes represent anatomical brain regions and edges indicate the occurrence of fiber tracts between them, has enabled an objective graph-theoretic analysis of human connectomes. However, the latent structure on higher-order interactions remains unexplored, where many brain regions act in synergy to perform complex functions. Here we use the simplicial complexes description of human connectome, where the shared simplexes encode higher-order relationships between groups of nodes. We study consensus connectome of 100 female (F-connectome) and of 100 male (M-connectome) subjects that we generated from the Budapest Reference Connectome Server v3.0 based on data from the Human Connectome Project. Our analysis reveals that the functional geometry of the common F&M-connectome coincides with the M-connectome and is characterized by a complex architecture of simplexes to the 14th order, which is built in six anatomical communities, and linked by short cycles. The F-connectome has additional edges that involve different brain regions, thereby increasing the size of simplexes and introducing new cycles. Both connectomes contain characteristic subjacent graphs that make them 3/2-hyperbolic. These results shed new light on the functional architecture of the brain, suggesting that insightful differences among connectomes are hidden in their higher-order connectivity.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.rightsReconocimiento-NoComercial-CompartirIgual 3.0 Españaen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/en_US
dc.subjectBrainen_US
dc.subjectConnectivityen_US
dc.subjectDecompositionen_US
dc.subjectSex differencesen_US
dc.subjectHyperbolicityen_US
dc.subjectNetworksen_US
dc.subjectArchitecture and graphsen_US
dc.subjectHuman Connectomeen_US
dc.titleFunctional Geometry of Human Connectomesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-019-48568-5.pdfen_US
dc.relation.projectIDES/1PE/SEV-2017-0718en_US
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionen_US
dc.journal.titleSCIENTIFIC REPORTSen_US


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Reconocimiento-NoComercial-CompartirIgual 3.0 España
Except where otherwise noted, this item's license is described as Reconocimiento-NoComercial-CompartirIgual 3.0 España