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dc.contributor.authorLawson, C.E.
dc.contributor.authorHarcombe, W.R.
dc.contributor.authorHatzenpichler, R.
dc.contributor.authorNoguera, D.R.
dc.contributor.authorMcMahon, K.D.
dc.contributor.authorLindemann, S.R.
dc.contributor.authorLoffler, F.E.
dc.contributor.authorO'Malley, M.A.
dc.contributor.authorGarcia-Martin, H.
dc.contributor.authorPfleger, B.F.
dc.contributor.authorRaskin, L.
dc.contributor.authorVenturelli, O.S.
dc.contributor.authorWeissbrodt, D.G.
dc.description.abstractDespite broad scientific interest in harnessing the power of Earth's microbiomes, knowledge gaps hinder their efficient use for addressing urgent societal and environmental challenges. We argue hat structuring research and technology developments around a design-build-test-learn (DBTL) cycle will advance microbiome engineering and spur new discoveries on the basic scientific principles governing microbiome function. In this Review, we present key elements of an iterative DBTL cycle for microbiome engineering, focusing on generalizable approaches, including top-down and bottom-up design processes, synthetic and self-assembled construction methods, and emerging tools to analyze microbiome function. These approaches can be used to harness microbiomes for broad applications related to medicine, agriculture, energy, and the environment. We also discuss key challenges and opportunities of each approach and synthesize them into best practice guidelines for engineering microbiomes. We anticipate that adoption of a DBTL framework will rapidly advance microbiome-based biotechnologies aimed at improving human and animal health, agriculture, and enabling the bioeconomy.en_US
dc.rightsReconocimiento-NoComercial-CompartirIgual 3.0 Españaen_US
dc.titleCommon principles and best practices for engineering microbiomesen_US
dc.journal.titleNature reviewsen_US

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Reconocimiento-NoComercial-CompartirIgual 3.0 España
Except where otherwise noted, this item's license is described as Reconocimiento-NoComercial-CompartirIgual 3.0 España