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dc.contributor.authorFülöp, T.
dc.contributor.authorDesroches, M. 
dc.contributor.authorCohen, A.
dc.contributor.authorSantos, F.A.N.
dc.contributor.authorRodrigues, S. 
dc.date.accessioned2020-12-28T19:20:44Z
dc.date.available2020-12-28T19:20:44Z
dc.date.issued2020-10-27
dc.identifier.urihttp://hdl.handle.net/20.500.11824/1226
dc.description.abstractLiving systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be understood and eventually reversed? What tools can be employed to further our understanding of ageing? The present article is an invitation for biologists and clinicians to consider key conceptual ideas and computational tools (known to mathematicians and physicists), which potentially may help dissect some of the underlying processes of ageing and disease. Specifically, we first discuss how to classify and analyse complex systems, as well as highlight critical theoretical difficulties that make complex systems hard to study. Subsequently, we introduce Topological Data Analysis - a novel Big Data tool – which may help in the study of complex systems since it extracts knowledge from data in a holistic approach via topological considerations. These conceptual ideas and tools are discussed in a relatively informal way to pave future discussions and collaborations between mathematicians and biologists studying ageing.en_US
dc.description.sponsorshipBasque Government under the grant “Artificial Intelligence in BCAM number EXP. 2019/00432” Inria associated team "NeuroTransSF"en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.rightsReconocimiento-NoComercial-CompartirIgual 3.0 Españaen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/en_US
dc.titleWhy we should use topological data analysis in ageing: Towards defining the “topological shape of ageing”en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.1016/j.mad.2020.111390
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S004763742030186Xen_US
dc.relation.projectIDES/1PE/SEV-2017-0718en_US
dc.relation.projectIDES/2PE/RTI2018-093860-B-C21en_US
dc.relation.projectIDEUS/BERC/BERC.2018-2021en_US
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen_US
dc.journal.titleMechanisms of Ageing and Developmenten_US


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Reconocimiento-NoComercial-CompartirIgual 3.0 España
Except where otherwise noted, this item's license is described as Reconocimiento-NoComercial-CompartirIgual 3.0 España