Now showing items 106-125 of 263

• #### Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change ﻿

(2022-04-01)
Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as ...
• #### Impact of competitive processes on controlled radical polymerization ﻿

(2014-12-31)
The kinetics of radical polymerization have been systematically studied for nearly a century and in general are well understood. However, in light of recent developments in controlled radical polymerization many kinetic ...
• #### The Impact of Serotype Cross-Protection on Vaccine Trials: DENVax as a Case Study ﻿

(2020-11)
There is a growing public health need for effective preventive interventions against dengue, and a safe, effective and affordable dengue vaccine against the four serotypes would be a significant achievement for disease ...
• #### Incorporating landscape heterogeneities in the spread of an epidemics in wildlife ﻿

(2014-12-31)
One of the main difficulties in the modeling and numerical simulation of the spread of an infectious disease in wildlife resides in properly taking into account the heterogeneities of the landscape. Forests, plains and ...
• #### Inflection, Canards and Folded Singularities in Excitable Systems: Application to a 3D FitzHugh–Nagumo Model ﻿

(2020-09-07)
Specific kinds of physical and biological systems exhibit complex Mixed-Mode Oscillations mediated by folded-singularity canards in the context of slow-fast models. The present manuscript revisits these systems, specifically ...
• #### Influence of electromechanical effects and wetting layers on band structures of AlN/GaN quantum dots and spin control ﻿

(2010-12-31)
In a series of recent papers we demonstrated that coupled electromechanical effects can lead to pronounced contributions in band structure calculations of low dimensional semiconductor nanostructures (LDSNs) such as quantum ...
• #### Information Flow between Resting-State Networks ﻿

(2015-12-31)
The resting brain dynamics self-organize into a finite number of correlated patterns known as resting-state networks (RSNs). It is well known that techniques such as independent component analysis can separate the brain ...
• #### Interference mechanism of seemingly superluminal tunneling ﻿

(2013-12-31)
Apparently "superluminal" transmission, e.g., in quantum tunneling and its variants, occurs via a subtle interference mechanism which allows reconstruction of the entire spatial shape of a wave packet from its front tail. ...
• #### An introduction to mathematical and numerical modeling in heart electrophysiology ﻿

(2016)
The electrical activation of the heart is the biological process that regulates the contraction of the cardiac muscle, allowing it to pump blood to the whole body. In physiological conditions, the pacemaker cells of the ...
• #### Is minimising the convergence rate a good choice for efficient optimized schwarz preconditioning in heterogeneous coupling? The Stokes-Darcy case ﻿

(2019-01-05)
• #### Is minimising the convergence rate the best choice for efficient Optimized Schwarz preconditioning in heterogeneous coupling? The Stokes-Darcy case ﻿

(2019)
Optimized Schwarz Methods (OSM) are domain decomposition techniques based on Robin-type interface condition that have became increasingly popular in the last two decades. Ensuring convergence also on non-overlapping ...
• #### The JBEI quantitative metabolic modeling library (jQMM): a python library for modeling microbial metabolism ﻿

(2017-01-01)
Modeling of microbial metabolism is a topic of growing importance in biotechnology. Mathematical modeling helps provide a mechanistic understanding for the studied process, separating the main drivers from the circumstantial ...
• #### Key aspects for effective mathematical modelling of fractional-diffusion in cardiac electrophysiology: A quantitative study ﻿

(2020-05)
Microscopic structural features of cardiac tissue play a fundamental role in determining complex spatio-temporal excitation dynamics at the macroscopic level. Recent efforts have been devoted to the development of mathematical ...
• #### Kinetic Parameter Estimation from Spectroscopic Data for a Multi-Stage Solid-Liquid Pharmaceutical Process ﻿

(2020-08-07)
Laboratory and process measurements from spectroscopic instruments are ubiquitous in pharma processes, and directly using the data can pose a number of challenges for kinetic model building. Moreover, scaling up from ...
• #### Lagged and instantaneous dynamical influences related to brain structural connectivity ﻿

(2015-12-31)
Contemporary neuroimaging methods can shed light on the basis of human neural and cognitive specializations, with important implications for neuroscience and medicine. Indeed, different MRI acquisitions provide different ...
• #### Large-scale simulations of synthetic markets ﻿

(2015-10-08)
High-frequency trading has been experiencing an increase of interest both for practical purposes within nancial institutions and within academic research; recently, the UK Government O ce for Science reviewed the state ...
• #### A least-squares implicit RBF-FD closest point method and applications to PDEs on moving surfaces ﻿

(2018-10)
The closest point method (Ruuth and Merriman, J. Comput. Phys. 227(3):1943-1961, [2008]) is an embedding method developed to solve a variety of partial differential equations (PDEs) on smooth surfaces, using a closest point ...
• #### Lessons from Two Design–Build–Test–Learn Cycles of Dodecanol Production in Escherichia coli Aided by Machine Learning ﻿

(2019-01-01)
The Design–Build–Test–Learn (DBTL) cycle, facilitated by exponentially improving capabilities in synthetic biology, is an increasingly adopted metabolic engineering framework that represents a more systematic and efficient ...
• #### Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy ﻿

(2015-12-31)
Brain Functional Connectivity (FC) quantifies statistical dependencies between areas of the brain. FC has been widely used to address altered function of brain circuits in control conditions compared to different pathological ...
• #### Low-traffic limit and first-passage times for a simple model of the continuous double auction ﻿

(2017-05)
We consider a simplified model of the continuous double auction where prices are integers varying from 1 to $N$ with limit orders and market orders, but quantity per order limited to a single share. For this model, the ...