Now showing items 238-257 of 263

• #### Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease ﻿

(2021-05-04)
Alzheimer’s disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease. The etiology of AD is not known but AD may be considered as a clinical syndrome with multiple ...
• #### Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease ﻿

(2020-05-26)
Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of ...
• #### Temporal excitation patterns on the cerebral cortex as a result of migraine modeling ﻿

(2016-06-29)
The complex, highly individual, geometry of the cerebral cortex in humans presents a major challenge in studying the spreading of spontaneous neuronal activity. Recent computational advances [1] allow to simulate the ...
• #### The airfoil equation on near disjoint intervals: Approximate models and polynomial solutions ﻿

(2016-01-01)
The airfoil equation is considered over two disjoint intervals. Assuming the distance between the intervals is small an approximate solution is found and relationships between this approximation and the solution of the ...
• #### A theoretical approach for the electrochemical characterization of ciliary epithelium ﻿

(2020-01-23)
The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion. Modulation of ionic secretion is a fundamental target for ...
• #### Theoretical Study of the Dissociative Adsorption of Methane on Ir(111): The Role of Steps and Surface Distortions at High Temperatures ﻿

(2016-01-01)
In this work we revisit the dissociative adsorption of methane on Ir(111) through density functional theory calculations. We focus on the role of surface defects entailing undercoordinated Ir atoms (e.g., steps), and ...
• #### Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions ﻿

(2020-03)
Percutaneous thermal ablation has proved to be an effective modality for treating both benign and malignant tumors in various tissues. Among these modalities, radiofrequency ablation (RFA) is the most promising and widely ...
• #### Three Dimensional Metallic Carbon from Distorting sp3-Bond ﻿

(2016-01-01)
Owing to the outstanding properties of metallic carbon as well as their great potential applications, design and synthesis of metallic carbon have long attracted considerable attention. In this work, a new three-dimensional ...
• #### Tissue drives lesion: computational evidence of interspecies variability in cardiac radiofrequency ablation ﻿

(2019)
Radiofrequency catheter ablation (RFCA) is widely used for the treatment of various types of cardiac arrhythmias. Typically, the efficacy and the safety of the ablation protocols used in the clinics are derived from tests ...
• #### A Tool for Custom Construction of QMC and RQMC Point Sets ﻿

(2021)
We present LatNet Builder, a software tool to find good parameters for lattice rules, polynomial lattice rules, and digital nets in base 2, for quasi-Monte Carlo (QMC) and randomized quasi-Monte Carlo (RQMC) sampling over ...
• #### The topology of higher-order complexes associated with brain hubs in human connectomes ﻿

(2020-12-01)
Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry ...
• #### Transitions between bursting modes in the integrated oscillator model for pancreatic β-cells ﻿

(2018-06-20)
Insulin-secreting $\beta$-cells of pancreatic islets of Langerhans produce bursts of electrical impulses, resulting in intracellular Ca$^{2+}$ oscillations and pulsatile insulin secretion. The mechanism for this bursting ...
• #### Traveling waves for models of phase transitions of solids driven by configurational forces ﻿

(2011-12-31)
This article is concerned with the existence of traveling wave solutions, including standing waves, to some models based on configurational forces, describing respectively the diffusionless phase transitions of solid ...
• #### Tuning $g$-factor of electrons through spin-orbit coupling in GaAs/AlGaAs conical quantum dots ﻿

(2016-01-01)
We investigate band structures of (Formula presented.) three-dimensional conical quantum dots (QDs). In particular, we explore the influence of the Rashba and Dresselhaus spinâ€“orbit couplings in the variation of effective ...
• #### Tunnelling times, Larmor clock, and the elephant in the room ﻿

(2021-05-11)
A controversy surrounding the “tunnelling time problem” stems from the seeming inability of quantum mechanics to provide, in the usual way, a definition of the duration a particle is supposed to spend in a given region of ...
• #### Two types of condition for the global stability of delayed sis epidemic models with nonlinear birth rate and disease induced death rate ﻿

(2012-12-31)
We study global asymptotic stability for an SIS epidemic model with maturation delay proposed by K. Cooke, P. van den Driessche and X. Zou, Interaction of maturation delay and nonlinear birth in population and epidemic ...
• #### Understanding COVID-19 Epidemics: A Multi-Scale Modeling Approach ﻿

(2022-02-18)
COVID-19 was declared a pandemic by the World Health Organization in March 2020 and, since then, research on mathematical modeling became imperative and very influential to understand the epidemiological dynamics of disease ...
• #### Unlocking datasets by calibrating populations of models to data density: a study in atrial electrophysiology ﻿

(2018-01-10)
The understanding of complex physical or biological systems nearly always requires a characterization of the variability that underpins these processes. In addition, the data used to calibrate these models may also often ...
• #### Unveiling Interfacial Li-Ion Dynamics in Li7La3Zr2O12/PEO(LiTFSI) Composite Polymer-Ceramic Solid Electrolytes for All-Solid-State Lithium Batteries ﻿

(2021-06-23)
Unlocking the full potential of solid-state electrolytes (SSEs) is key to enabling safer and more-energy dense technologies than today’s Li-ion batteries. In particular, composite materials comprising a conductive, flexible ...
• #### Using discrete Ricci curvatures to infer COVID-19 epidemic network fragility and systemic risk ﻿

(2021)
The damage of the novel Coronavirus disease (COVID-19) is reaching unprecedented scales. There are numerous classical epidemiology models trying to quantify epidemiology metrics. Usually, to forecast epidemics, classical ...