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Chemoinformatic-guided engineering of polyketide synthases
Polyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A central challenge in PKS design is replacing a partially reductive module with a ...
Predictive engineering and optimization of tryptophan metabolism in yeast through a combination of mechanistic and machine learning models
In combination with advanced mechanistic modeling and the generation of high-quality multi-dimensional data sets, machine learning is becoming an integral part of understanding and engineering living systems. Here we show ...