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Within-host models unravelling the dynamics of dengue reinfections
(2024-02-07)
Caused by four serotypes, dengue fever is a major public health concern worldwide. Current modeling efforts have mostly focused on primary and heterologous secondary infections, assuming that lifelong immunity prevents ...
Symmetry in a multi-strain epidemiological model with distributed delay as a general cross-protection period and disease enhancement factor
(2024-01)
Important biological features of viral infectious diseases caused by multiple agents with interacting strain dynamics continue to pose challenges for mathematical modelling development. Motivated by dengue fever epidemiology, ...
Cost-effectiveness analysis of vaccines for COVID-19 according to sex, comorbidity and socioeconomics status: a population study
(2023-11-01)
Background and Objective
Coronavirus disease 2019 (COVID-19) vaccines are extremely effective in preventing severe disease, but their real-world cost-effectiveness is still an open question. We present an analysis of the ...
The effects of public health measures on severe dengue cases: An optimal control approach
(2023-07)
Dengue fever is the most important viral mosquito-borne disease worldwide, with approximately 3.9 billion people at risk of acquiring dengue infection. Measures against mosquito bite combined with vector control programs ...
Optimal vaccine allocation for the control of sexually transmitted infections
(2023-04-15)
The burden of sexually transmitted infections (STIs) poses a challenge due to its
large negative impact on sexual and reproductive health worldwide. Besides simple
prevention measures and available treatment efforts, ...
The effect of mixed vaccination rollout strategy: A modelling study
(2023-03-10)
Vaccines have measurable efficacy obtained first from vaccine trials. However, vaccine efficacy (VE) is not a static measure and long-term population studies are needed to evaluate its performance and impact. COVID-19 ...
Modeling secondary infections with temporary immunity and disease enhancement factor: Mechanisms for complex dynamics in simple epidemiological models
(2022-10-04)
Modeling insights for epidemiological scenarios characterized by chaotic dynamics have been largely unexplored. A rigorous analysis of such systems are essential for a real predictive power and a more accurate disease ...
Modeling the initial phase of COVID-19 epidemic: The role of age and disease severity in the Basque Country, Spain
(2022-07-13)
Declared a pandemic by the World Health Organization (WHO), COVID-19 has spread rapidly around the globe. With eventually substantial global underestimation of infection, by the end of March 2022, more than 470 million ...
Modeling Dengue Immune Responses Mediated by Antibodies: Insights on the Biological Parameters to Describe Dengue Infections
(2022-03-18)
Dengue fever is a viral mosquito-borne disease, a significant global health concern, with more than one third of the world population at risk of acquiring the disease. Caused by 4 antigenically distinct but related virus ...