Now showing items 1-5 of 5
Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease. The etiology of AD is not known but AD may be considered as a clinical syndrome with multiple ...
Spike-adding and reset-induced canard cycles in adaptive integrate and fire models
We study a class of planar integrate and fire (IF) models called adaptive integrate and fire (AIF) models, which possesses an adaptation vari- able on top of membrane potential, and whose subthreshold dynamics is piece- ...
Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing”
Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be ...
Inflection, Canards and Folded Singularities in Excitable Systems: Application to a 3D FitzHugh–Nagumo Model
Specific kinds of physical and biological systems exhibit complex Mixed-Mode Oscillations mediated by folded-singularity canards in the context of slow-fast models. The present manuscript revisits these systems, specifically ...
Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of ...