Mathematical Modelling in Biosciences
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A least-squares implicit RBF-FD closest point method and applications to PDEs on moving surfaces
(Journal of Computational Physics, 2018-10)The closest point method (Ruuth and Merriman, J. Comput. Phys. 227(3):1943-1961, [2008]) is an embedding method developed to solve a variety of partial differential equations (PDEs) on smooth surfaces, using a closest point ... -
Computational modeling of open-irrigated electrodes for radiofrequency cardiac ablation including blood motion-saline flow interaction
(PLoS One, 2016)Radiofrequency catheter ablation (RFCA) is a routine treatment for cardiac arrhythmias. During RFCA, the electrode-tissue interface temperature should be kept below 80°C to avoid thrombus formation. Open-irrigated electrodes ... -
Computational Model for Prediction of the Occurrence of Steam Pops during Irrigated Radiofrequency Catheter Ablation
(Computing in Cardiology 43, 2016)Radiofrequency catheter ablation (RFCA) is a curative treatment for cardiac arrhythmias. Although globally a pretty safe procedure, it may present some risk. Steam pop is a serious complication that can occur during RFCA ... -
Effect of Tissue Elasticity in Cardiac Radiofrequency Catheter Ablation Models
(2018)Radiofrequency catheter ablation (RFCA) is an effective treatment for different types of cardiac arrhythmias. However, major complications can occur, including thrombus formation and steam pops. We present a full 3D ... -
A computational model of open-irrigated radiofrequency catheter ablation accounting for mechanical properties of the cardiac tissue
(2018)Radiofrequency catheter ablation (RFCA) is an effective treatment for cardiac arrhythmias. Although generally safe, it is not completely exempt from the risk of complications. The great flexibility of computational models ... -
Modelling Cortical Spreading Depression by a computational algorithm of distributed neural excitability: correlation with clinical features in single migraine with aura patients
(Journal of Headache and Pain 18 (Suppl. 1), 2017) -
Is minimising the convergence rate the best choice for efficient Optimized Schwarz preconditioning in heterogeneous coupling? The Stokes-Darcy case
(2019)Optimized Schwarz Methods (OSM) are domain decomposition techniques based on Robin-type interface condition that have became increasingly popular in the last two decades. Ensuring convergence also on non-overlapping ... -
Optimized Schwarz Methods in the Stokes-Darcy Coupling
(IMA J. Num. Analysis 38 (4), 2018-10-16)This article studies optimized Schwarz methods for the Stokes–Darcy problem. Robin transmission conditions are introduced, and the coupled problem is reduced to a suitable interface system that can be solved using Krylov ... -
An introduction to mathematical and numerical modeling in heart electrophysiology
(2016)The electrical activation of the heart is the biological process that regulates the contraction of the cardiac muscle, allowing it to pump blood to the whole body. In physiological conditions, the pacemaker cells of the ... -
Modeling cardiac structural heterogeneity via space-fractional differential equations
(Computational and Mathematical Biomedical Engineering (CMBE2017) Proceedings, 2017)We discuss here the use of non-local models in space and fractional order operators in the characterisation of structural complexity and the modeling of propagation in heterogeneous biological tissues. In the specific, we ... -
A computational model integrating brain electrophysiology and metabolism highlights the key role of extracellular potassium and oxygen
(Journal of Theoretical Biology, 2018-02-26)The human brain is a small organ which uses a disproportional amount of the total metabolic energy pro- duction in the body. While it is well understood that the most significant energy sink is the maintenance of the ... -
Transitions between bursting modes in the integrated oscillator model for pancreatic β-cells
(Journal of Theoretical Biology, 2018-06-20)Insulin-secreting $\beta$-cells of pancreatic islets of Langerhans produce bursts of electrical impulses, resulting in intracellular Ca$^{2+}$ oscillations and pulsatile insulin secretion. The mechanism for this bursting ... -
An RBF-FD closest point method for solving PDEs on surfaces
(Journal of Computational Physics, 2018)Partial differential equations (PDEs) on surfaces appear in many applications throughout the natural and applied sciences. The classical closest point method (Ruuth and Merriman, J. Comput. Phys. 227(3):1943-1961, ... -
Unlocking datasets by calibrating populations of models to data density: a study in atrial electrophysiology
(Science Advances, 2018-01-10)The understanding of complex physical or biological systems nearly always requires a characterization of the variability that underpins these processes. In addition, the data used to calibrate these models may also often ... -
A space-fractional Monodomain model for cardiac electrophysiology combining anisotropy and heterogeneity on realistic geometries
(2017-10-04)Classical models of electrophysiology do not typically account for the effects of high structural heterogeneity in the spatio-temporal description of excitation waves propagation. We consider a modification of the Monodomain ... -
Discretizations of the spectral fractional Laplacian on general domains with Dirichlet, Neumann, and Robin boundary conditions
(2017-04-28)In this work, we propose novel discretisations of the spectral fractional Laplacian on bounded domains based on the integral formulation of the operator via the heat-semigroup formalism. Specifically, we combine suitable ... -
Structuring targeted surveillance for monitoring disease emergence by mapping observational data onto ecological process
(Journal of the Royal Society Interface, 2013-12-31)An efficient surveillance system is a crucial factor in identifying, monitoring and tackling outbreaks of infectious diseases. Scarcity of data and limited amounts of economic resources require a targeted effort from public ... -
Numerical simulation of a susceptible-exposed-infectious space-continuous model for the spread of rabies in raccoons across a realistic landscape
(Journal of Biological Dynamics, 2013-12-31)We introduce a numerical model for the spread of a lethal infectious disease in wildlife. The reference model is a Susceptible-Exposed-Infectious system where the spatial component of the dynamics is modelled by a diffusion ... -
Optimized schwarz methods for the bidomain system in electrocardiology
(Mathematical Modelling and Numerical Analysis, 2013-12-31)The propagation of the action potential in the heart chambers is accurately described by the Bidomain model, which is commonly accepted and used in the specialistic literature. However, its mathematical structure of a ... -
Spectral analysis of a block-triangular preconditioner for the bidomain system in electrocardiology
(Electronic Transactions on Numerical Analysis, 2012-12-31)In this paper we analyze in detail the spectral properties of the block-triangular preconditioner introduced by Gerardo-Giorda et al. [J. Comput. Phys., 228 (2009), pp. 3625-3639] for the Bidomain system in non-symmetric ...
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