Browsing Mathematical Modelling in Biosciences by Title
Now showing items 1-20 of 75
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A computational model of open-irrigated electrode for endocardial RF catheter ablation
(2016-01-01)Radiofrequency catheter ablation (RFCA) is an important curative treatment for cardiac arrhythmias. However, during RFCA thrombus formation can occur when the electrode-tissue interface temperature exceeds 80°C. Open-irrigated ... -
Advanced Mathematical Modelling of Pancreatic β-Cells
(2019-12-10)Insulin-secreting pancreatic $\beta$-cells are responsible for maintaining the whole body glucose homeostasis. Dysfunction or loss of $\beta$-cell mass results in impaired insulin secretion and, in some cases, diabetes. ... -
Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: evidence from an integrated computational model
(2019-06-05)The energetic needs of brain cells at rest and during elevated neuronal activation has been the topic of many investigations where mathematical models have played a significant role providing a context for the interpretation ... -
Chronic stimulation induces adaptive potassium channel activity that restores calcium oscillations in pancreatic islets in vitro
(2020-04-01)Insulin pulsatility is important to hepatic response in regulating blood glucose. Growing evidence suggests that insulin-secreting pancreatic β-cells can adapt to chronic disruptions of pulsatility to rescue this physiologically ... -
Clinical correlates of mathematical modeling of cortical spreading depression: Single‐cases study
Kroos, J.M.; de Tommaso, M.; Stramaglia, S.
; Vecchio, E.; Burdi, N.; Gerardo-Giorda, L. (2019-07-28)
Introduction: Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis ... -
Comparative analysis of different methods of modeling the thermal effect of circulating blood flow during RF cardiac ablation
(2016-01-01)Our aim was to compare the different methods of modeling the effect of circulating blood flow on the thermal lesion dimensions created by radio frequency (RF) cardiac ablation and on the maximum blood temperature. Computational ... -
Computational Model for Prediction of the Occurrence of Steam Pops during Irrigated Radiofrequency Catheter Ablation
(2016)Radiofrequency catheter ablation (RFCA) is a curative treatment for cardiac arrhythmias. Although globally a pretty safe procedure, it may present some risk. Steam pop is a serious complication that can occur during RFCA ... -
A computational model integrating brain electrophysiology and metabolism highlights the key role of extracellular potassium and oxygen
(2018-02-26)The human brain is a small organ which uses a disproportional amount of the total metabolic energy pro- duction in the body. While it is well understood that the most significant energy sink is the maintenance of the ... -
A computational model of open-irrigated radiofrequency catheter ablation accounting for mechanical properties of the cardiac tissue
(2018)Radiofrequency catheter ablation (RFCA) is an effective treatment for cardiac arrhythmias. Although generally safe, it is not completely exempt from the risk of complications. The great flexibility of computational models ... -
Computational modeling of open-irrigated electrodes for radiofrequency cardiac ablation including blood motion-saline flow interaction
(2016)Radiofrequency catheter ablation (RFCA) is a routine treatment for cardiac arrhythmias. During RFCA, the electrode-tissue interface temperature should be kept below 80°C to avoid thrombus formation. Open-irrigated electrodes ... -
A computational multiscale model of cortical spreading depression propagation
(2016-12-19)Cortical Spreading Depression (CSD) is a disruption of the brain hemostasis that, originating in the visual cortex and traveling towards the frontal lobe, temporarily impairs the normal functioning of neurons. Although, ... -
Computational predictive modeling of integrated cerebral metabolism, electrophysiology and hemodynamics
(2019-02-12)Understanding the energetic requirement of brain cells during resting state and during high neuronal activity is a very active research area where mathematical models have contributed significantly by providing a context ... -
Condition-specific mortality risk can explain differences in COVID-19 case fatality ratios around the globe
Aguiar, M.; Stollenwerk, N. (2020-09)
Objectives With COVID-19 infections resulting in death according to a hierarchy of risks, with age and pre-existing health conditions enhancing disease severity, the objective of this study is to estimate the condition-specific ... -
Critical fluctuations in epidemic models explain COVID‑19 post‑lockdown dynamics
Aguiar, M.; BidaurrazagaVan‑Dierdonc, J.; Mar, J.; Cusimano, N.; Knopoff, D.A.; Anam, V.; Stollenwerk, N. (2021-07-06)
As the COVID-19 pandemic progressed, research on mathematical modeling became imperative and very influential to understand the epidemiological dynamics of disease spreading. The momentary reproduction ratio r(t) of an ... -
Cross immunity protection and antibody-dependent enhancement in a distributed delay dynamic model
(2022-01-01)Dengue fever is endemic in tropical and subtropical countries, and certain important features of the spread of dengue fever continue to pose challenges for mathematical modelling. Here we propose a system of integro-differential ... -
Deterministic and Stochastic Dynamics of COVID-19: The Case Study of Italy and Spain
Srivastav, A. K.; Stollenwerk, N.; Aguiar, M. (2022-02-13)
In December 2019, a severe respiratory syndrome (COVID-19) caused by a new coronavirus (SARS-CoV-2) was identified in China and spread rapidly around the globe. COVID-19 was declared a pandemic by the World Health Organization ... -
Discretizations of the spectral fractional Laplacian on general domains with Dirichlet, Neumann, and Robin boundary conditions
Cusimano, N.; Del Teso, F.; Gerardo-Giorda, L.; Pagnini, G. (2017-04-28)
In this work, we propose novel discretisations of the spectral fractional Laplacian on bounded domains based on the integral formulation of the operator via the heat-semigroup formalism. Specifically, we combine suitable ... -
Effect of General Cross-Immunity Protection and Antibody- Dependent Enhancement in Dengue Dynamics
Steindorf, V; Oliva, S.; Wu, J.; Aguiar, M. (2022-02-13)
A mathematical model to describe the dynamic of a multiserotype infectious disease at the population level is studied. Applied to dengue fever epidemiology, we analyse a mathematical model with time delay to describe the ... -
Effect of Tissue Elasticity in Cardiac Radiofrequency Catheter Ablation Models
(2018)Radiofrequency catheter ablation (RFCA) is an effective treatment for different types of cardiac arrhythmias. However, major complications can occur, including thrombus formation and steam pops. We present a full 3D ... -
Estimation of age-specific rates of reactivation and immune boosting of the varicella zoster virus
Marinelli, I.; van Lier, A.; de Melker, H.; Pugliese, A.; van Boven, M. (2016-12-31)
Studies into the impact of vaccination against the varicella zoster virus (VZV) have increasingly focused on herpes zoster (HZ), which is believed to be increasing in vaccinated populations with decreasing infection pressure. ...