Browsing Mathematical Modelling in Biosciences by Title
Now showing items 1-20 of 62
-
A computational model of open-irrigated electrode for endocardial RF catheter ablation
(2016-01-01)Radiofrequency catheter ablation (RFCA) is an important curative treatment for cardiac arrhythmias. However, during RFCA thrombus formation can occur when the electrode-tissue interface temperature exceeds 80°C. Open-irrigated ... -
Advanced Mathematical Modelling of Pancreatic β-Cells
(2019-12-10)Insulin-secreting pancreatic $\beta$-cells are responsible for maintaining the whole body glucose homeostasis. Dysfunction or loss of $\beta$-cell mass results in impaired insulin secretion and, in some cases, diabetes. ... -
Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: evidence from an integrated computational model
(2019-06-05)The energetic needs of brain cells at rest and during elevated neuronal activation has been the topic of many investigations where mathematical models have played a significant role providing a context for the interpretation ... -
Clinical correlates of mathematical modeling of cortical spreading depression: Single‐cases study
Kroos, J.M.; de Tommaso, M.; Stramaglia, S.
; Vecchio, E.; Burdi, N.; Gerardo-Giorda, L. (2019-07-28)
Introduction: Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis ... -
Comparative analysis of different methods of modeling the thermal effect of circulating blood flow during RF cardiac ablation
(2016-01-01)Our aim was to compare the different methods of modeling the effect of circulating blood flow on the thermal lesion dimensions created by radio frequency (RF) cardiac ablation and on the maximum blood temperature. Computational ... -
Computational Model for Prediction of the Occurrence of Steam Pops during Irrigated Radiofrequency Catheter Ablation
(2016)Radiofrequency catheter ablation (RFCA) is a curative treatment for cardiac arrhythmias. Although globally a pretty safe procedure, it may present some risk. Steam pop is a serious complication that can occur during RFCA ... -
A computational model integrating brain electrophysiology and metabolism highlights the key role of extracellular potassium and oxygen
(2018-02-26)The human brain is a small organ which uses a disproportional amount of the total metabolic energy pro- duction in the body. While it is well understood that the most significant energy sink is the maintenance of the ... -
A computational model of open-irrigated radiofrequency catheter ablation accounting for mechanical properties of the cardiac tissue
(2018)Radiofrequency catheter ablation (RFCA) is an effective treatment for cardiac arrhythmias. Although generally safe, it is not completely exempt from the risk of complications. The great flexibility of computational models ... -
Computational modeling of open-irrigated electrodes for radiofrequency cardiac ablation including blood motion-saline flow interaction
(2016)Radiofrequency catheter ablation (RFCA) is a routine treatment for cardiac arrhythmias. During RFCA, the electrode-tissue interface temperature should be kept below 80°C to avoid thrombus formation. Open-irrigated electrodes ... -
A computational multiscale model of cortical spreading depression propagation
(2016-12-19)Cortical Spreading Depression (CSD) is a disruption of the brain hemostasis that, originating in the visual cortex and traveling towards the frontal lobe, temporarily impairs the normal functioning of neurons. Although, ... -
Computational predictive modeling of integrated cerebral metabolism, electrophysiology and hemodynamics
(2019-02-12)Understanding the energetic requirement of brain cells during resting state and during high neuronal activity is a very active research area where mathematical models have contributed significantly by providing a context ... -
Condition-specific mortality risk can explain differences in COVID-19 case fatality ratios around the globe
Aguiar, M.; Stollenwerk, N. (2020-09)
Objectives With COVID-19 infections resulting in death according to a hierarchy of risks, with age and pre-existing health conditions enhancing disease severity, the objective of this study is to estimate the condition-specific ... -
Critical fluctuations in epidemic models explain COVID‑19 post‑lockdown dynamics
Aguiar, M.; BidaurrazagaVan‑Dierdonc, J.; Mar, J.; Cusimano, N.; Knopoff, D.; Anam, V.; Stollenwerk, N. (2021-07-06)
As the COVID-19 pandemic progressed, research on mathematical modeling became imperative and very influential to understand the epidemiological dynamics of disease spreading. The momentary reproduction ratio r(t) of an ... -
Discretizations of the spectral fractional Laplacian on general domains with Dirichlet, Neumann, and Robin boundary conditions
Cusimano, N.; Del Teso, F.; Gerardo-Giorda, L.; Pagnini, G. (2017-04-28)
In this work, we propose novel discretisations of the spectral fractional Laplacian on bounded domains based on the integral formulation of the operator via the heat-semigroup formalism. Specifically, we combine suitable ... -
Effect of Tissue Elasticity in Cardiac Radiofrequency Catheter Ablation Models
(2018)Radiofrequency catheter ablation (RFCA) is an effective treatment for different types of cardiac arrhythmias. However, major complications can occur, including thrombus formation and steam pops. We present a full 3D ... -
Estimation of age-specific rates of reactivation and immune boosting of the varicella zoster virus
Marinelli, I.; van Lier, A.; de Melker, H.; Pugliese, A.; van Boven, M. (2016-12-31)
Studies into the impact of vaccination against the varicella zoster virus (VZV) have increasingly focused on herpes zoster (HZ), which is believed to be increasing in vaccinated populations with decreasing infection pressure. ... -
Ethics of a partially effective dengue vaccine: Lessons from the Philippines
Halstead, B.S.; Katzelnick, L.C.; Russell, P.K.; Markoff, L.; Aguiar, M.; Dans, L.R.; Dans A , L. (2020-07)
Dengvaxia, a chimeric yellow fever tetravalent dengue vaccine developed by SanofiPasteur is widely licensed in dengue-endemic countries. In a large cohort study Dengvaxia was found to partially protect children who had ... -
Extreme brain events: Higher-order statistics of brain resting activity and its relation with structural connectivity
Amor, T.A.; Russo, R.; Diez, I.; Bharath, P.; Zirovich, M.; Stramaglia, S.; Cortes, J.M.; de Arcangelis, L.; Chialvo, D.R. (2015-12-31)
The brain exhibits a wide variety of spatiotemporal patterns of neuronal activity recorded using functional magnetic resonance imaging as the so-called blood-oxygenated-level-dependent (BOLD) signal. An active area of work ... -
Functional connectivity of EEG signals under laser stimulation in migraine
de Tommaso, M.; Trotta, G.; Vecchio, E.; Ricci, K.; Van de Steen, F.; Montemurno, A.; Lorenzo, M.; Marinazzo, D.; Bellotti, R.; Stramaglia, S. (2015-12-31)
In previous studies, migraine patients showed abnormalities in pain-related evoked responses, as reduced habituation to repetitive stimulation. In this study, we aimed to apply a novel analysis of EEG bands synchronization ... -
Geometry shapes propagation: Assessing the presence and absence of cortical symmetries through a computational model of cortical spreading depression
Kroos, J.M.; Diez, I.; Cortes, J.M.; Stramaglia, S.; Gerardo-Giorda, L. (2015-12-31)
Cortical spreading depression (CSD), a depolarization wave which originates in the visual cortex and travels toward the frontal lobe, has been suggested to be one neural correlate of aura migraine. To the date, little is ...