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Clinical correlates of mathematical modeling of cortical spreading depression: Single‐cases study
(2019-07-28)
Introduction: Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis ...
Patient-specific modelling of cortical spreading depression applied to migraine studies
(2019-06-17)
Migraine is a common neurological disorder and one-third of migraine patients suffer from migraine aura, a perceptual disturbance preceding the typically unilateral headache. Cortical spreading depression (CSD), a ...
SDE-driven modeling of phenotypically heterogeneous tumors: The influence of cancer cell stemness
(2019)
We deduce cell population models describing the evolution of a tumor (possibly interacting with its environment of healthy cells) with the aid of differential equations. Thereby, different subpopulations of cancer cells ...
A computational multiscale model of cortical spreading depression propagation
(2016-12-19)
Cortical Spreading Depression (CSD) is a disruption of the brain hemostasis that, originating in the visual cortex and traveling towards the frontal lobe, temporarily impairs the normal functioning of neurons. Although, ...
Patient-specific computational modeling of Cortical Spreading Depression via Diffusion Tensor Imaging
(2016-06-29)
Cortical Spreading Depression (CSD), a depolarization wave originat- ing in the visual cortex and traveling towards the frontal lobe, is com- monly accepted as a correlate of migraine visual aura. As of today, little is ...
Temporal excitation patterns on the cerebral cortex as a result of migraine modeling
(2016-06-29)
The complex, highly individual, geometry of the cerebral cortex in humans presents a major challenge in studying the spreading of spontaneous neuronal activity. Recent computational advances [1] allow to simulate the ...
Geometry shapes propagation: Assessing the presence and absence of cortical symmetries through a computational model of cortical spreading depression
(2015-12-31)
Cortical spreading depression (CSD), a depolarization wave which originates in the visual cortex and travels toward the frontal lobe, has been suggested to be one neural correlate of aura migraine. To the date, little is ...