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Advanced Mathematical Modelling of Pancreatic β-Cells
(2019-12-10)
Insulin-secreting pancreatic $\beta$-cells are responsible for maintaining the whole body glucose homeostasis. Dysfunction or loss of $\beta$-cell mass results in impaired insulin secretion and, in some cases, diabetes. ...
Meta-modeling on detailed geography for accurate prediction of invasive alien species dispersal
(2019-11-07)
Invasive species are recognized as a significant threat to biodiversity. The mathematical modeling of their spatio-temporal dynamics can provide significant help to environmental managers in devising suitable control ...
Clinical correlates of mathematical modeling of cortical spreading depression: Single‐cases study
(2019-07-28)
Introduction: Considerable connections between migraine with aura and cortical spreading depression (CSD), a depolarization wave originating in the visual cortex and traveling toward the frontal lobe, lead to the hypothesis ...
Patient-specific modelling of cortical spreading depression applied to migraine studies
(2019-06-17)
Migraine is a common neurological disorder and one-third of migraine patients suffer from migraine aura, a perceptual disturbance preceding the typically unilateral headache. Cortical spreading depression (CSD), a ...
Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: evidence from an integrated computational model
(2019-06-05)
The energetic needs of brain cells at rest and during elevated neuronal activation has been the topic of many investigations where mathematical models have played a significant role providing a context for the interpretation ...
Computational predictive modeling of integrated cerebral metabolism, electrophysiology and hemodynamics
(2019-02-12)
Understanding the energetic requirement of brain cells during resting state and during high neuronal activity is a very active research area where mathematical models have contributed significantly by providing a context ...
Is minimising the convergence rate the best choice for efficient Optimized Schwarz preconditioning in heterogeneous coupling? The Stokes-Darcy case
(2019)
Optimized Schwarz Methods (OSM) are domain decomposition techniques based on Robin-type interface condition that have became increasingly popular in the last two decades. Ensuring convergence also on non-overlapping ...
How does radiofrequency ablation efficacy depend on the stiffness of the cardiac tissue? Insights from a computational model
(2019)
Objective. Radiofrequency catheter ablation (RFCA) is an effective treatment for the
elimination of cardiac arrhythmias, however it is not exempt from complications that can
risk the patients’ life. The efficacy of the ...
Glioma invasion and its interplay with the nervous tissue: a multiscale model
(2019)
A multiscale mathematical model for glioma cell migration and proliferation is proposed, taking into account a possible therapeutic approach. Starting with the description of processes taking place on the subcellular level, ...