Mathematical Modelling in Biosciences
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Withinhost models unravelling the dynamics of dengue reinfections
(20240207)Caused by four serotypes, dengue fever is a major public health concern worldwide. Current modeling efforts have mostly focused on primary and heterologous secondary infections, assuming that lifelong immunity prevents ... 
Symmetry in a multistrain epidemiological model with distributed delay as a general crossprotection period and disease enhancement factor
(202401)Important biological features of viral infectious diseases caused by multiple agents with interacting strain dynamics continue to pose challenges for mathematical modelling development. Motivated by dengue fever epidemiology, ... 
Optimal vaccination strategies for a heterogenous population using multiple objectives: The case of L1 and L2formulations
(202312)The choice of the objective functional in optimization problems coming from biomedical and epidemiological applications plays a key role in optimal control outcomes. In this study, we investigate the role of the objective ... 
Costeffectiveness analysis of vaccines for COVID19 according to sex, comorbidity and socioeconomics status: a population study
(20231101)Background and Objective Coronavirus disease 2019 (COVID19) vaccines are extremely effective in preventing severe disease, but their realworld costeffectiveness is still an open question. We present an analysis of the ... 
Changes in Social and Clinical Determinants of COVID19 Outcomes Achieved by the Vaccination Program: A Nationwide Cohort Study
(2022)Background: The objective of this study was to assess changes in social and clinical determinants of COVID19 outcomes associated with the first year of COVID19 vaccination rollout in the Basque population. Methods: A ... 
Datadriven estimation of the instantaneous reproduction number and growth rates for the 2022 monkeypox outbreak in Europe
(20230913)Objective: To estimate the instantaneous reproduction number $R_t$ and the epidemic growth rates for the 2022 monkeypox outbreaks in the European region. Methods: We gathered daily laboratoryconfirmed monkeypox cases in ... 
The effects of public health measures on severe dengue cases: An optimal control approach
(202307)Dengue fever is the most important viral mosquitoborne disease worldwide, with approximately 3.9 billion people at risk of acquiring dengue infection. Measures against mosquito bite combined with vector control programs ... 
A Spatial Kinetic Model of Crowd Evacuation Dynamics with Infectious Disease Contagion
(20230401)This paper proposes a kinetic theory approach coupling together the modeling of crowd evacuation from a bounded domain with exit doors and infectious disease contagion. The spatial movement of individuals in the crowd is ... 
Optimal vaccine allocation for the control of sexually transmitted infections
(20230415)The burden of sexually transmitted infections (STIs) poses a challenge due to its large negative impact on sexual and reproductive health worldwide. Besides simple prevention measures and available treatment efforts, ... 
Modeling the transmission dynamics and vaccination strategies for human papillomavirus infection: An optimal control approach
(202212)Human papillomavirus (HPV) vaccines have been introduced in several countries and have shown positive results in reducing HPV infection and related diseases. Nevertheless, immunization programs remain suboptimal and more ... 
The effect of mixed vaccination rollout strategy: A modelling study
(20230310)Vaccines have measurable efficacy obtained first from vaccine trials. However, vaccine efficacy (VE) is not a static measure and longterm population studies are needed to evaluate its performance and impact. COVID19 ... 
Analysis of the initial phase of COVID19 epidemics in Italy: a modeling study
(20221022)This thesis describes the first years of COVID19 pandemic in Italy. We started looking at the data given by the Italian Civil Protection and according to the trend we nally described the epidemiological curve through a ... 
Numerical computing approach for solving HunterSaxton equation arising in liquid crystal model through sinc collocation method
(20210721)In this study, numerical treatment of liquid crystal model described through HunterSaxton equation (HSE) has been presented by sinc collocation technique through theta weighted scheme due to its enormous applications ... 
Understanding COVID19 Epidemics: A MultiScale Modeling Approach
(20220218)COVID19 was declared a pandemic by the World Health Organization in March 2020 and, since then, research on mathematical modeling became imperative and very influential to understand the epidemiological dynamics of disease ... 
Modeling secondary infections with temporary immunity and disease enhancement factor: Mechanisms for complex dynamics in simple epidemiological models
(20221004)Modeling insights for epidemiological scenarios characterized by chaotic dynamics have been largely unexplored. A rigorous analysis of such systems are essential for a real predictive power and a more accurate disease ... 
Modeling the initial phase of COVID19 epidemic: The role of age and disease severity in the Basque Country, Spain
(20220713)Declared a pandemic by the World Health Organization (WHO), COVID19 has spread rapidly around the globe. With eventually substantial global underestimation of infection, by the end of March 2022, more than 470 million ... 
Modeling Dengue Immune Responses Mediated by Antibodies: Insights on the Biological Parameters to Describe Dengue Infections
(20220318)Dengue fever is a viral mosquitoborne disease, a significant global health concern, with more than one third of the world population at risk of acquiring the disease. Caused by 4 antigenically distinct but related virus ... 
Seasonally Forced SIR Systems Applied to Respiratory Infectious Diseases, Bifurcations, and Chaos
(20220303)We investigate models to describe respiratory diseases with fast mutating virus pathogens such that after some years the aquired resistance is lost and hosts can be infected with new variants of the pathogen. Such models ... 
Mathematical models for dengue fever epidemiology: a 10year systematic review
(20220215)Mathematical models have a long history in epidemiological research, and as the COVID19 pandemic progressed, research on mathematical modeling became imperative and very influential to understand the epidemiological ...