Mathematical Modelling in Biosciences
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Modeling Dengue Immune Responses Mediated by Antibodies: Insights on the Biological Parameters to Describe Dengue Infections
(20220318)Dengue fever is a viral mosquitoborne disease, a significant global health concern, with more than one third of the world population at risk of acquiring the disease. Caused by 4 antigenically distinct but related virus ... 
Seasonally Forced SIR Systems Applied to Respiratory Infectious Diseases, Bifurcations, and Chaos
(20220303)We investigate models to describe respiratory diseases with fast mutating virus pathogens such that after some years the aquired resistance is lost and hosts can be infected with new variants of the pathogen. Such models ... 
Mathematical models for dengue fever epidemiology: a 10year systematic review
(20220215)Mathematical models have a long history in epidemiological research, and as the COVID19 pandemic progressed, research on mathematical modeling became imperative and very influential to understand the epidemiological ... 
Cross immunity protection and antibodydependent enhancement in a distributed delay dynamic model
(20220101)Dengue fever is endemic in tropical and subtropical countries, and certain important features of the spread of dengue fever continue to pose challenges for mathematical modelling. Here we propose a system of integrodifferential ... 
Effect of General CrossImmunity Protection and Antibody Dependent Enhancement in Dengue Dynamics
(20220213)A mathematical model to describe the dynamic of a multiserotype infectious disease at the population level is studied. Applied to dengue fever epidemiology, we analyse a mathematical model with time delay to describe the ... 
Deterministic and Stochastic Dynamics of COVID19: The Case Study of Italy and Spain
(20220213)In December 2019, a severe respiratory syndrome (COVID19) caused by a new coronavirus (SARSCoV2) was identified in China and spread rapidly around the globe. COVID19 was declared a pandemic by the World Health Organization ... 
Modelling Holling type II functional response in deterministic and stochastic food chain models with mass conservation
(20220301)The RosenzweigMacArthur predatorprey model is the building block in modeling food chain, food webs and ecosystems. There are a number of hidden assumptions involved in the derivation. For instance the prey population ... 
Spatially Extended SHAR Epidemiological Framework of Infectious Disease Transmission
(20220213)Mathematical models play an important role in epidemiology. The inclusion of a spatial component in epidemiological models is especially important to understand and address many relevant ecological and public health ... 
The role of mild and asymptomatic infections on COVID19 vaccines performance: A modeling study
(20211116)Introduction: Different COVID19 vaccine efficacies are reported, with remarkable effectiveness against severe disease. The so called sterilizing immunity, occurring when vaccinated individuals cannot transmit the virus, ... 
Modeling and optimal control of dengue disease with screening and information
(20211127)This study presents a mathematical model for dengue transmission which quantifies two very important aspects: one, the impact of informationbased behavioural response, and the other, the segregation of infected human ... 
Systematic Characterization of HighPower ShortDuration Ablation: Insight From an Advanced Virtual Model
(2021)Highpower shortduration (HPSD) recently emerged as a new approach to radiofrequency (RF) catheter ablation. However, basic and clinical data supporting its effectiveness and safety is still scarce 
Chronic stimulation induces adaptive potassium channel activity that restores calcium oscillations in pancreatic islets in vitro
(20200401)Insulin pulsatility is important to hepatic response in regulating blood glucose. Growing evidence suggests that insulinsecreting pancreatic βcells can adapt to chronic disruptions of pulsatility to rescue this physiologically ... 
Modeling dengue immune responses mediated by antibodies: A qualitative study
(20210901)Dengue fever is a viral mosquitoborne infection and a major international public health concern. With 2.5 billion people at risk of acquiring the infection around the world, disease severity is influenced by the immunological ... 
A multiscale networkbased model of contagion dynamics: heterogeneity, spatial distancing and vaccination
(2021)Lockdown and vaccination policies have been the major concern in the last year in order to contain the SARSCoV2 infection during the COVID19 pandemic. In this paper we present a model able to evaluate alternative lockdown ... 
What is life? A perspective of the mathematical kinetic theory of active particles
(2021)The modeling of living systems composed of many interacting entities is treated in this paper with the aim of describing their collective behaviors. The mathematical approach is developed within the general framework of ... 
Critical fluctuations in epidemic models explain COVID‑19 post‑lockdown dynamics
(20210706)As the COVID19 pandemic progressed, research on mathematical modeling became imperative and very influential to understand the epidemiological dynamics of disease spreading. The momentary reproduction ratio r(t) of an ... 
A spacefractional bidomain framework for cardiac electrophysiology: 1D alternans dynamics
(2021)Cardiac electrophysiology modeling deals with a complex network of excitable cells forming an intricate syncytium: the heart. The electrical activity of the heart shows recurrent spatial patterns of activation, known as ... 
Mathematical models for glioma growth and migration inside the brain
(202101)Gliomas are the most prevalent, aggressive, and invasive subtype of primary brain tumors, characterized by rapid cell proliferation and great infiltration capacity. De spite the advances of clinical research, these tumors ... 
The Impact of Serotype CrossProtection on Vaccine Trials: DENVax as a Case Study
(202011)There is a growing public health need for effective preventive interventions against dengue, and a safe, effective and affordable dengue vaccine against the four serotypes would be a significant achievement for disease ... 
Modeling COVID19: Challenges and results
(202010)Weird times we are living in. While lots of technological, medical and scientific advances are generated in a short period of time, we are now fighting a pandemic, trying to stop the spread of a new virus that has not only ...