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dc.contributor.authorDe Pittà, M. 
dc.contributor.authorBrunel, N.
dc.date.accessioned2022-11-15T07:39:48Z
dc.date.available2022-11-15T07:39:48Z
dc.date.issued2022-10-25
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/20.500.11824/1535
dc.description.abstractPersistent activity in populations of neurons, time-varying activity across a neural population, or activity-silent mechanisms carried out by hidden internal states of the neural population have been proposed as different mechanisms of working memory (WM). Whether these mechanisms could be mutually exclusive or occur in the same neuronal circuit remains, however, elusive, and so do their biophysical underpinnings. While WM is traditionally regarded to depend purely on neuronal mechanisms, cortical networks also include astrocytes that can modulate neural activity. We propose and investigate a network model that includes both neurons and glia and show that glia-synapse interactions can lead to multiple stable states of synaptic transmission. Depending on parameters, these interactions can lead in turn to distinct patterns of network activity that can serve as substrates for WM.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.rightsReconocimiento-NoComercial-CompartirIgual 3.0 Españaen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/en_US
dc.subjectgliotransmissionen_US
dc.subjectneuron–glial networksen_US
dc.subjectspiking neuron and astrocyte modelsen_US
dc.subjectworking memoryen_US
dc.titleMultiple forms of working memory emerge from synapse-astrocyte interactions in a neuron-glia network modelen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.1073/pnas.2207912119en_US
dc.relation.publisherversionhttps://www.pnas.org/doi/10.1073/pnas.2207912119en_US
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.type.hasVersioninfo:eu-repo/semantics/submittedVersionen_US
dc.journal.titleProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.volume.number119en_US
dc.issue.number43en_US


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Reconocimiento-NoComercial-CompartirIgual 3.0 España
Except where otherwise noted, this item's license is described as Reconocimiento-NoComercial-CompartirIgual 3.0 España