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dc.contributor.authorBarrio, I. 
dc.contributor.authorEspaña, P.P
dc.contributor.authorVillanueva, A
dc.contributor.authorGascon, M
dc.contributor.authorLarrea, N. 
dc.contributor.authorGarcía-Gutiérrez, S.
dc.contributor.authorQuintana, J.M.
dc.contributor.authorPortuondo-Jimenez, J.
dc.description.abstractObjective: We identify factors related to SARS-CoV-2 infection linked to hospitalization, ICU admission, and mortality and develop clinical prediction rules. Methods: Retrospective cohort study of 380,081 patients with SARS-CoV-2 infection from March 1, 2020 to January 9, 2022, including a subsample of 46,402 patients who attended Emergency Departments (EDs) having data on vital signs. For derivation and external validation of the prediction rule, two different periods were considered: before and after emergence of the Omicron variant, respectively. Data collected included sociodemographic data, COVID-19 vaccination status, baseline comorbidities and treatments, other background data and vital signs at triage at EDs. The predictive models for the EDs and the whole samples were developed using multivariate logistic regression models using Lasso penalization. Results: In the multivariable models, common predictive factors of death among EDs patients were greater age; being male; having no vaccination, dementia; heart failure; liver and kidney disease; hemiplegia or paraplegia; coagulopathy; interstitial pulmonary disease; malignant tumors; use chronic systemic use of steroids, higher temperature, low O2 saturation and altered blood pressure-heart rate. The predictors of an adverse evolution were the same, with the exception of liver disease and the inclusion of cystic fibrosis. Similar predictors were found to be related to hospital admission, including liver disease, arterial hypertension, and basal prescription of immunosuppressants. Similarly, models for the whole sample, without vital signs, are presented. Conclusions: We propose risk scales, based on basic information, easily-calculable, high-predictive that also function with the current Omicron variant and may help manage such patients in primary, emergency, and hospital care. Keywords: COVID-19; Clinical decision rules; Health care; Outcome assessment; SARS-CoV-2.en_US
dc.rightsReconocimiento-NoComercial-CompartirIgual 3.0 Españaen_US
dc.subjectClinical decision rulesen_US
dc.subjectHealth careen_US
dc.subjectOutcome assessmenten_US
dc.titleClinical prediction rules for adverse evolution in patients with COVID-19 by the Omicron varianten_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001142-Sen_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115882RB-I00en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno Vasco/BMTFen_US
dc.journal.titleInternational Journal of Medical Informaticsen_US

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Reconocimiento-NoComercial-CompartirIgual 3.0 España
Except where otherwise noted, this item's license is described as Reconocimiento-NoComercial-CompartirIgual 3.0 España