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dc.contributor.authorKroos J.M.en_US
dc.contributor.authorGerardo-Giorda L.en_US
dc.date.accessioned2016-12-19T13:48:06Z
dc.date.available2016-12-19T13:48:06Z
dc.date.issued2016-12-19
dc.identifier.issn0898-1221
dc.identifier.urihttp://hdl.handle.net/20.500.11824/336
dc.description.abstractCortical Spreading Depression (CSD) is a disruption of the brain hemostasis that, originating in the visual cortex and traveling towards the frontal lobe, temporarily impairs the normal functioning of neurons. Although, as of today, little is known about the mechanisms that can trigger or stop such phenomenon, CSD is commonly accepted as a correlate of migraine visual aura. In this paper, we introduce a multiscale PDE-ODE model that couples the propagation of the depolarization wave associated to CSD with a detailed electrophysiological model for the neuronal activity to capture both macroscopic and microscopic dynamics.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherComputers and Mathematics with Applications
dc.relationES/1PE/SEV-2013-0323en_US
dc.relationES/1PE/MTM2015-69992-Ren_US
dc.relationEUS/BERC/BERC.2014-2017en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/en_US
dc.subjectCortical Spreading Depressionen_US
dc.subjectPDE-ODE coupled systemsen_US
dc.subjectFinite elementsen_US
dc.subjectMultiscale modelingen_US
dc.titleA computational multiscale model of cortical spreading depression propagationen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeinfo:eu-repo/semantics/publishedVersionen_US
dc.identifier.doi10.1016/j.camwa.2017.05.013
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0898122117303024


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