Show simple item record

dc.contributor.authorPaliy, M.
dc.contributor.authorMelnik, R.
dc.contributor.authorShapiro, B.A.
dc.date.accessioned2017-02-21T08:16:50Z
dc.date.available2017-02-21T08:16:50Z
dc.date.issued2010-12-31
dc.identifier.issn1478-3967
dc.identifier.urihttp://hdl.handle.net/20.500.11824/456
dc.description.abstractA series of coarse-grained models have been developed for study of the molecular dynamics of RNA nanostructures. The models in the series have one to three beads per nucleotide and include different amounts of detailed structural information. Such a treatment allows us to reach, for systems of thousands of nucleotides, a time scale of microseconds (i.e. by three orders of magnitude longer than in full atomistic modeling) and thus to enable simulations of large RNA polymers in the context of bionanotechnology. We find that the three-beads-per-nucleotide models, described by a set of just a few universal parameters, are able to describe different RNA conformations and are comparable in structural precision to the models where detailed values of the backbone P-C4′ dihedrals taken from a reference structure are included. These findings are discussed in the context of RNA conformation classes. © 2010 IOP Publishing Ltd.
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsReconocimiento-NoComercial-CompartirIgual 3.0 Españaen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/en_US
dc.titleCoarse-graining RNA nanostructures for molecular dynamics simulations
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doi10.1088/1478-3975/7/3/036001
dc.relation.publisherversionhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78349248253&doi=10.1088%2f1478-3975%2f7%2f3%2f036001&partnerID=40&md5=1313b4f38a8104b73912073d9873a1db
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_US
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionen_US
dc.journal.titlePhysical Biologyen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Reconocimiento-NoComercial-CompartirIgual 3.0 España
Except where otherwise noted, this item's license is described as Reconocimiento-NoComercial-CompartirIgual 3.0 España