High-accuracy adaptive modeling of the energy distribution of a meniscus-shaped cell culture in a Petri dish
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We introduce a general computational fixed-point method to prove existence of periodic solutions of differential delay equations with multiple time lags. The idea of such a method is to compute numerical approximations of periodic solutions using Newton's method applied on a finite dimensional projection, to derive a set of analytic estimates to bound the truncation error term and finally to use this explicit information to verify computationally the hypotheses of a contraction mapping theorem in a given Banach space. The fixed point so obtained gives us the desired periodic solution. We provide two applications. The first one is a proof of coexistence of three periodic solutions for a given delay equation with two time lags, and the second one provides rigorous computations of several nontrivial periodic solutions for a delay equation with three time lags.