Recent Submissions

  • Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease 

    Fülöp, T.; Tripathi, S.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Bunt, T.; Eiser, A.; Bernier, F.; Beauregard, P.; Barron, A.; Khalil, A.; Plotka, A.; Hirokawa, K.; Larbi, A.; Bocti, C.; Laurent, B.; Frost, E.; Witkowski, J. (2021-05-04)
    Alzheimer’s disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease. The etiology of AD is not known but AD may be considered as a clinical syndrome with multiple ...
  • Spike-adding and reset-induced canard cycles in adaptive integrate and fire models 

    Desroches, M.Autoridad BCAM; Kowalczyk, P.; Rodrigues, S.Autoridad BCAM (2021-05-03)
    We study a class of planar integrate and fire (IF) models called adaptive integrate and fire (AIF) models, which possesses an adaptation vari- able on top of membrane potential, and whose subthreshold dynamics is piece- ...
  • Inflection, Canards and Folded Singularities in Excitable Systems: Application to a 3D FitzHugh–Nagumo Model 

    Uria-Albizuri, J.; Desroches, M.Autoridad BCAM; Krupa, M.; Rodrigues, S.Autoridad BCAM (2020-09-07)
    Specific kinds of physical and biological systems exhibit complex Mixed-Mode Oscillations mediated by folded-singularity canards in the context of slow-fast models. The present manuscript revisits these systems, specifically ...
  • Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing” 

    Fülöp, T.; Desroches, M.Autoridad BCAM; Cohen, A.; Santos, F.A.N.; Rodrigues, S.Autoridad BCAM (2020-10-27)
    Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be ...
  • Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease 

    Fülöp, T.; Munawara, U.; Larbi, A.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Catanzaro, M.; Guidolin, A.; Khalil, A.; Bernier, F.; Barron, A.E.; Hirokawa, K.; Beauregard, P.B.; Dumoulin, D.; Bellenger, J.-P.; Witkowski, J.M.; Frost, E. (2020-05-26)
    Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of ...
  • Neuron-glial Interactions 

    De Pitta, M. (2020-06-07)
    Although lagging behind classical computational neuroscience, theoretical and computational approaches are beginning to emerge to characterize different aspects of neuron-glial interactions. This chapter aims to provide ...
  • Grigorchuk-Gupta-Sidki groups as a source for Beauvile surfaces 

    Sükran, G.; Uria-Albizuri, J. (2020-04-14)
    If $G$ is a Grigorchuk-Gupta-Sidki group defined over a $p$-adic tree, where p is an odd prime, we study the existence of Beauville surfaces associated to the quotients of $G$ by its level stabilizers $st_G(n)$. We prove ...
  • A theoretical approach for the electrochemical characterization of ciliary epithelium 

    Sacco, R.; Guidoboni, G.; Jerome, J.W.; Bonifazi, G.Autoridad BCAM; Marazzi, N.M.; Vercellin, A.C.V.; Lang, M.S.; Harris, A. (2020-01-23)
    The ciliary epithelium (CE) is the primary site of aqueous humor (AH) production, which results from the combined action of ultrafiltration and ionic secretion. Modulation of ionic secretion is a fundamental target for ...
  • Computing Multipersistence by Means of Spectral Systems 

    Guidolin, A.; Divasón, J.; Romero, A.Autoridad BCAM; Vaccarino, F. (2019-07-08)
    In their original setting, both spectral sequences and persistent homology are algebraic topology tools defined from filtrations of objects (e.g. topological spaces or simplicial complexes) indexed over the set Z of integer ...
  • A roadmap to integrate astrocytes into Systems Neuroscience 

    Kastanenka Ksenia, V.; Poskanzer Kira, E.; Galea, E.; Moreno-Bote, R.; De Pittà, M.Autoridad BCAM; Perea, G.; Eraso-Pichot, A.; Masgrau, R. (2019-05-06)
    Systems Neuroscience is still mainly a neuronal field, despite the plethora of evidence supporting the fact that astrocytes modulate local neural circuits, networks, and complex behaviors. In this article, we sought to ...
  • Metastable resting state brain dynamics 

    beim Graben, P.; Jimenez-Marin, A.; Diez, I.; Cortes, J.M.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM (2019-09-06)
    Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ...
  • Conductance-Based Refractory Density Approach for a Population of Bursting Neurons 

    Chizhov, A.; Campillo, F.; Desroches, M.Autoridad BCAM; Guillamon A; Rodrigues, S.Autoridad BCAM (2019)
    The conductance-based refractory density (CBRD) approach is a parsimonious mathematical-computational framework for modeling interact- ing populations of regular spiking neurons, which, however, has not been yet extended ...
  • Anticipation via canards in excitable systems 

    Köksal Ersöz, E.; Desroches, M.Autoridad BCAM; Mirasso, C.; Rodrigues, S.Autoridad BCAM (2019-01-14)
    Neurons can anticipate incoming signals by exploiting a physiological mechanism that is not well understood. This article offers a novel explanation on how a receiver neuron can predict the sender’s dynamics in a ...
  • Pro-C congruence properties for groups of rooted tree automorphisms 

    Garrido, A.; Uria-Albizuri, J. (2018-11-21)
    We propose a generalisation of the congruence subgroup problem for groups acting on rooted trees. Instead of only comparing the profinite completion to that given by level stabilizers, we also compare pro-$\mathcal{C}$ ...
  • Multi-GGS groups have the congruence subgroup property 

    Garrido, A.; Uria-Albizuri, J. (2018-11-08)
    We generalize the result about the congruence subgroup property for GGS-groups to the family of multi-GGS-groups; that is, all multi-GGS-groups except the one defined by the constant vector have the congruence subgroup ...