Now showing items 1-8 of 8

    • Anticipation via canards in excitable systems 

      Köksal Ersöz, E.; Desroches, M.Autoridad BCAM; Mirasso, C.; Rodrigues, S.Autoridad BCAM (2019-01-14)
      Neurons can anticipate incoming signals by exploiting a physiological mechanism that is not well understood. This article offers a novel explanation on how a receiver neuron can predict the sender’s dynamics in a ...
    • Conductance-Based Refractory Density Approach for a Population of Bursting Neurons 

      Chizhov, A.; Campillo, F.; Desroches, M.Autoridad BCAM; Guillamon A; Rodrigues, S.Autoridad BCAM (2019)
      The conductance-based refractory density (CBRD) approach is a parsimonious mathematical-computational framework for modeling interact- ing populations of regular spiking neurons, which, however, has not been yet extended ...
    • Inflection, Canards and Folded Singularities in Excitable Systems: Application to a 3D FitzHugh–Nagumo Model 

      Uria-Albizuri, J.; Desroches, M.Autoridad BCAM; Krupa, M.; Rodrigues, S.Autoridad BCAM (2020-09-07)
      Specific kinds of physical and biological systems exhibit complex Mixed-Mode Oscillations mediated by folded-singularity canards in the context of slow-fast models. The present manuscript revisits these systems, specifically ...
    • Metastable resting state brain dynamics 

      beim Graben, P.; Jimenez-Marin, A.; Diez, I.; Cortes, J.M.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM (2019-09-06)
      Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ...
    • Spike-adding and reset-induced canard cycles in adaptive integrate and fire models 

      Desroches, M.Autoridad BCAM; Kowalczyk, P.; Rodrigues, S.Autoridad BCAM (2021-05-03)
      We study a class of planar integrate and fire (IF) models called adaptive integrate and fire (AIF) models, which possesses an adaptation vari- able on top of membrane potential, and whose subthreshold dynamics is piece- ...
    • Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease 

      Fülöp, T.; Tripathi, S.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Bunt, T.; Eiser, A.; Bernier, F.; Beauregard, P.; Barron, A.; Khalil, A.; Plotka, A.; Hirokawa, K.; Larbi, A.; Bocti, C.; Laurent, B.; Frost, E.; Witkowski, J. (2021-05-04)
      Alzheimer’s disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease. The etiology of AD is not known but AD may be considered as a clinical syndrome with multiple ...
    • Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease 

      Fülöp, T.; Munawara, U.; Larbi, A.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Catanzaro, M.; Guidolin, A.; Khalil, A.; Bernier, F.; Barron, A.E.; Hirokawa, K.; Beauregard, P.B.; Dumoulin, D.; Bellenger, J.-P.; Witkowski, J.M.; Frost, E. (2020-05-26)
      Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of ...
    • Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing” 

      Fülöp, T.; Desroches, M.Autoridad BCAM; Cohen, A.; Santos, F.A.N.; Rodrigues, S.Autoridad BCAM (2020-10-27)
      Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be ...